公开(公告)号：US20150216765A1

公开(公告)日：2015-08-06

申请号：US14574515

申请日：2014-12-18

Applicant: MAILLEFER INSTRUMENTS HOLDING Sarl

Inventor： Benjamin LE OUAY ,  Francesco STELLACCI ,  Janine CONDE ,  Selma MEFTI

IPC: A61K6/00

CPC classification number: A61K6/0035 ,  A61K6/0002 ,  A61K8/0241 ,  A61K8/19 ,  A61K8/22 ,  A61K8/25 ,  A61K2800/413 ,  A61K2800/621 ,  A61K2800/651 ,  A61K2800/882 ,  A61L2/0088 ,  A61L2/238 ,  A61Q11/00

Abstract: A set of a first and a second preparation are intended to be mixed before or during an endodontic treatment to form an endodontic irrigation solution. The first preparation includes an oxidizing agent. The second preparation includes antibacterial nanoparticles treated to slow their oxidation by the oxidizing agent. The antibacterial nanoparticles are, for example, encapsulated in shells in a hybrid core-shell structure. In one variation, the antibacterial nanoparticles are made from an alloy of at least two elements, one of the elements being more resistant to oxidation than the other.

Abstract translation: 一组第一和第二制剂预期在牙根治疗之前或期间混合以形成牙髓灌洗溶液。 第一制剂包括氧化剂。 第二制剂包括经过氧化剂减缓其氧化的抗菌纳米颗粒。 例如，抗菌纳米颗粒被包封在混合的核 - 壳结构的壳中。 在一个实施方案中，抗菌纳米颗粒由至少两种元素的合金制成，其中一种元素比另一种元素更耐氧化。