公开(公告)号：US20240245709A1

公开(公告)日：2024-07-25

申请号：US18625718

申请日：2024-04-03

申请人： MARINUS PHARMACEUTICALS, INC.

发明人： Henrikas VAITKEVICIUS ,  Maciej Gasior ,  Joseph Hulihan

IPC分类号： A61K31/57 ,  A61K9/00 ,  A61K31/724

CPC分类号： A61K31/57 ,  A61K9/0019 ,  A61K31/724

摘要： This invention relates to methods for treating established status epilepticus (ESE) by administering to the subject in need thereof an intravenous bolus of ganaxolone and a continuous intravenous infusion of a neurosteroid. The method provides ESE suppression and continued suppression of ESE.

公开(公告)号：US20230364109A1

公开(公告)日：2023-11-16

申请号：US18321374

申请日：2023-05-22

申请人： MARINUS PHARMACEUTICALS, INC.

发明人： Henrikas VAITKEVICIUS ,  Maciej GASIOR ,  Joseph HULIHAN

IPC分类号： A61K31/573 ,  A61K9/00 ,  A61P25/08

CPC分类号： A61K31/573 ,  A61K9/0019 ,  A61P25/08

摘要： This invention relates to methods for treating super refractory status epilepticus by rapidly weaning the subject in need thereof off an anesthetic agent prior to initiation of administering to the subject in need thereof of ganaxolone at a high infusion dose. The method provides SE suppression and continued suppression of SE.