公开(公告)号：US20240140983A1

公开(公告)日：2024-05-02

申请号：US18262896

申请日：2022-01-26

Applicant: MASSEY UNIVERSITY

Inventor： Fareeda Maged Yahya BARZAK ,  Vyacheslav Vladimirovich FILICHEV ,  Elena HARJES ,  Stefan HARJES ,  Geoffrey Brind JAMESON ,  Harikrishnan Mohana KURUP ,  Maksim V. KVACH ,  Yongdong SU

IPC: C07H21/04

CPC classification number: C07H21/04

Abstract: The invention relates to single stranded DNA inhibitors of APOBEC3 enzymes and uses thereof. The compounds of the invention comprise β-D-5-O-phosphato-2-deoxyribofuranosyl analogues of nucleoside-like inhibitors of cytidine deaminase, flanked by oligonucleotide sequences which may be cross-linked. The compounds of the invention may have therapeutic application against diseases and conditions in which inhibition of a human cytidine deaminase of the APOBEC3 family would be beneficial.