公开(公告)号：US11279759B2

公开(公告)日：2022-03-22

申请号：US16570966

申请日：2019-09-13

Applicant: MEDIMMUNE, LLC

Inventor： Srinath Kasturirangan ,  Changshou Gao ,  Godfrey Rainey ,  Michelle Morrow ,  Claire Louise Dobson ,  Stacey Drabic ,  Darren Schofield ,  Gianluca Carlesso ,  Kristen Pollizzi ,  Yariv Mazor ,  Michael Oberst ,  Scott A. Hammond ,  Brian Lobo ,  Prakash Manikwar ,  Jonathan Seaman ,  Simon Dovedi ,  Ronald Herbst

IPC: C07K16/28

Abstract: The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides for specific binding proteins, including antibodies, which bind to a target protein. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making such proteins. The disclosure provides methods of inducing an immune response in a subject as well as methods for treating or preventing cancer in a subject by administering the proteins, nucleic acid molecules and/or compositions to the subject.

公开(公告)号：US10457732B2

公开(公告)日：2019-10-29

申请号：US15588271

申请日：2017-05-05

Applicant: MEDIMMUNE, LLC

Inventor： Srinath Kasturirangan ,  Changshou Gao ,  Godfrey Rainey ,  Michelle Morrow ,  Claire Louise Dobson ,  Stacey Drabic ,  Darren Schofield ,  Gianluca Carlesso ,  Kristen Pollizzi ,  Yariv Mazor ,  Michael Oberst ,  Scott A. Hammond ,  Brian Lobo ,  Prakash Manikwar ,  Jonathan Seaman ,  Simon Dovedi ,  Ronald Herbst

IPC: C07K16/28

Abstract: The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides for specific binding proteins, including antibodies, which bind to a target protein. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making such proteins. The disclosure provides methods of inducing an immune response in a subject as well as methods for treating or preventing cancer in a subject by administering the proteins, nucleic acid molecules and/or compositions to the subject.

公开(公告)号：USRE49908E1

公开(公告)日：2024-04-09

申请号：US17364539

申请日：2021-06-30

Applicant: MedImmune, LLC

Inventor： Srinath Kasturirangan ,  Changshou Gao ,  Godfrey Rainey ,  Michelle Morrow ,  Claire Louise Dobson ,  Stacey Drabic ,  Darren Schofield ,  Gianluca Carlesso ,  Kristen Pollizzi ,  Yariv Mazor ,  Michael Oberst ,  Scott A. Hammond ,  Brian Lobo ,  Prakash Manikwar ,  Jonathan Seaman ,  Simon Dovedi ,  Ronald Herbst

IPC: C07K16/28

CPC classification number: C07K16/2818 ,  C07K16/2803 ,  C07K16/2827 ,  C07K16/2878 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

Abstract: The disclosure generally provides proteins that bind two epitopes (e.g., a first and a second epitope) and that are bivalent for binding to each of the first and second epitopes. The disclosure also provides for specific binding proteins, including antibodies, which bind to a target protein. The disclosure also provides compositions comprising such proteins, nucleic acid molecules encoding such proteins and methods of making such proteins. The disclosure provides methods of inducing an immune response in a subject as well as methods for treating or preventing cancer in a subject by administering the proteins, nucleic acid molecules and/or compositions to the subject.