公开(公告)号：US11634424B2

公开(公告)日：2023-04-25

申请号：US17779310

申请日：2020-11-27

申请人： MEDSHINE DISCOVERY INC.

发明人： Yonggang Liao ,  Wenyuan Qian ,  Changqing Wei ,  Yao Xiao ,  Zhengying Xi ,  Chen Zhang ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D487/04 ,  A61P35/00

摘要： Disclosed are a diazaindole derivative as shown in formula I and the use thereof in the preparation of a drug for treating Chk1-related diseases.

公开(公告)号：US11254666B2

公开(公告)日：2022-02-22

申请号：US16621902

申请日：2018-06-13

申请人： MEDSHINE DISCOVERY INC.

发明人： Yonggang Liao ,  Chaonan Liu ,  Changqing Wei ,  Hao Wu ,  Shuhui Chen

IPC分类号： C07D417/14

摘要： A compound as a GLS1 inhibitor as represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US11230544B1

公开(公告)日：2022-01-25

申请号：US17284806

申请日：2019-10-15

申请人： MEDSHINE DISCOVERY INC.

发明人： Yonggang Liao ,  Jun Lin ,  Chaonan Liu ,  Changqing Wei ,  Wenyuan Qian ,  Chen Zhang ,  Zhen Gong ,  Jian Li ,  Shuhui Chen

IPC分类号： C07D285/135 ,  C07D417/14 ,  C07D417/12 ,  A61P35/00 ,  C07D487/04

摘要： Disclosed is to a thiadiazole derivative and the uses thereof in preparing a drug for treating GLS1-associated diseases. Specifically disclosed is a derivative compound of formula (I), a tautomer thereof or a pharmaceutically acceptable composition thereof.