公开(公告)号：US20220204507A1

公开(公告)日：2022-06-30

申请号：US17600994

申请日：2020-04-03

申请人： GUANGZHOU BAIYUNSHAN PHARMACEUTICAL HOLDINGS CO., LTD. BAIYUNSHAN PHARMACEUTICAL GENERAL FACTORY ,  MEDSHINE DISCOVERY INC.

发明人： Jiansong WANG ,  Zhifei FU ,  Zhibo LUO ,  Miaorong LUO ,  Yang ZHANG ,  Yalei CAI ,  Wu ZHU ,  Jian LI ,  Shuhui CHEN ,  Yingxia BAO ,  Wei WANG ,  Zhoufan XIE

IPC分类号： C07D471/10 ,  A61P35/00 ,  C07D401/14 ,  C07D413/14 ,  C07D498/10

摘要： Disclosed are a series of compounds with a nitrogen-containing spiro structure and an application thereof in the preparation of an RET kinase inhibitor. Specifically, disclosed is a compound as shown in formula (II) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230094146A1

公开(公告)日：2023-03-30

申请号：US17790985

申请日：2021-01-07

申请人： MEDSHINE DISCOVERY INC.

发明人： Zhifei FU ,  Miaorong LUO ,  Yang ZHANG ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D495/04

摘要： Disclosed is a deuterated thienopyridine compound. Specifically disclosed are a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.