公开(公告)号：US20220135588A1

公开(公告)日：2022-05-05

申请号：US17574817

申请日：2022-01-13

申请人： SCIWIND BIOSCIENCES CO., LTD ,  MEDSHINE DISCOVERY INC.

发明人： Tao YU ,  Lu GAN ,  Chengde WU ,  Shuhui CHEN

IPC分类号： C07D495/04 ,  C07D498/04 ,  C07D491/048 ,  C07D487/04 ,  C07D513/04 ,  A61P3/10

摘要： A novel five-membered heteroaromatic imidazole compound and use thereof is disclosed herein. Specifically, disclosed is a compound as shown in formula (III) or a pharmaceutically acceptable salt thereof. Also disclosed is a method for treating a disease related to GLP-1 receptor such as type II diabetes.

公开(公告)号：US20220112217A1

公开(公告)日：2022-04-14

申请号：US17270372

申请日：2019-08-21

申请人： MEDSHINE DISCOVERY INC.

发明人： Chengde WU ,  Jingjie HUANG ,  Tao YU ,  Jie LI ,  Zhen GONG ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D519/00 ,  A61P35/00

摘要： A series of pyrazolopyrimidine derivatives can be used in preparing a medicament for treating a disease related to PI3K. For example, a compound of formula (I), a tautomer thereof or a pharmaceutically acceptable composition thereof are effective in treating a disease related to P13K.

公开(公告)号：US20240239761A1

公开(公告)日：2024-07-18

申请号：US18549366

申请日：2022-03-18

申请人： MEDSHINE DISCOVERY INC.

发明人： Shengbin ZHANG ,  Tao YU ,  Chengde WU ,  Jinxin LIU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D271/07 ,  A61K31/4245

CPC分类号： C07D271/07 ,  A61K31/4245

摘要： A series of phenol compounds and the use thereof. Specifically disclosed are a compound as represented by formula (III) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230044606A1

公开(公告)日：2023-02-09

申请号：US17782850

申请日：2020-12-07

申请人： MEDSHINE DISCOVERY INC.

发明人： Yi LI ,  Ning LIU ,  Tao YU ,  Chengde WU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D513/20 ,  A61P35/00 ,  A61P1/00

摘要： A Spiro compound serving as an ERK inhibitor, and an application thereof in preparing a drug for treating an ERK-related disease. The present invention specifically relates to a compound represented by formula (III) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20220153772A1

公开(公告)日：2022-05-19

申请号：US17599308

申请日：2020-03-30

申请人： MEDSHINE DISCOVERY INC.

发明人： Yi LI ,  Tao YU ,  Qinghua MAO ,  Chengde WU ,  Shuhui CHEN

IPC分类号： C07H15/26 ,  A61P3/10 ,  A61P3/04

摘要： A glucoside derivative that acts as an SGLT1 inhibitor and an application thereof in the preparation of a drug for SGLT1 related diseases. Specifically disclosed is a compound represented by formula (II), a tautomer thereof or a pharmaceutically acceptable composition thereof.

公开(公告)号：US20230072937A1

公开(公告)日：2023-03-09

申请号：US17782814

申请日：2020-12-07

申请人： MEDSHINE DISCOVERY INC.

发明人： Yi LI ,  Ning LIU ,  Tao YU ,  Chengde WU ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D513/04 ,  A61P35/00

摘要： Provided are a thiazololactam compound, and the use thereof in the preparation of a drug for treating ERK-related diseases. Specially, the present invention provides a compound as shown in formula (III) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20220242898A1

公开(公告)日：2022-08-04

申请号：US17629527

申请日：2020-07-24

申请人： MEDSHINE DISCOVERY INC.

发明人： Qinghua MAO ,  Tao YU ,  Lu GAN ,  Yi LI ,  Chengde WU ,  Shuhui CHEN

IPC分类号： C07H7/06 ,  A61P3/10

摘要： Compounds as SGLT2/DPP4 dual inhibitors, and application in preparation of medicines as the SGLT2/DPP4 dual inhibitors. A compound represented by formula (I), and an isomer or pharmaceutically acceptable salt thereof are specifically involved.