公开(公告)号：US20240239763A1

公开(公告)日：2024-07-18

申请号：US18556896

申请日：2022-04-21

申请人： DONGBAO PURPLE STAR (HANGZHOU) BIOPHARMACEUTICAL CO., LTD. ,  MEDSHINE DISCOVERY INC.

发明人： Yang ZHANG ,  Wentao WU ,  Zhixiang LI ,  Wenyuan ZHU

IPC分类号： C07D333/72 ,  A61K31/381

CPC分类号： C07D333/72 ,  A61K31/381

摘要： Provided are a crystal form of a compound represented by formula (I) and a preparation method therefor.

公开(公告)号：US20230357248A1

公开(公告)日：2023-11-09

申请号：US17776873

申请日：2020-11-13

申请人： MEDSHINE DISCOVERY INC.

发明人： Yang ZHANG ,  Wentao WU ,  Kaijun GENG ,  Qiu LI ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D487/04 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61P35/00

摘要： Disclosed are a pyrrolopyrimidine compound and a use thereof in preparing a medicine for diseases related to a BTK protein kinase inhibitor. Specially, disclosed are a compound as shown in formula (III) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240217973A1

公开(公告)日：2024-07-04

申请号：US18554644

申请日：2022-04-15

申请人： MEDSHINE DISCOVERY INC.

发明人： Yang ZHANG ,  Wentao WU ,  Kaijun GENG ,  Rongxin HUANG ,  Shuhui CHEN

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/4545 ,  A61P37/00

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/4545 ,  A61P37/00

摘要： Provided are a series of imidazopyridine compounds and a use thereof, and in particular, relating to compounds as represented by formula (P), and pharmaceutically acceptable salts thereof.

公开(公告)号：US20230322703A1

公开(公告)日：2023-10-12

申请号：US17766435

申请日：2020-10-30

申请人： MEDSHINE DISCOVERY INC.

发明人： Yang ZHANG ,  Wentao WU ,  Wenyuan ZHU ,  Shuhui CHEN

IPC分类号： C07D495/04 ,  A61P19/06 ,  C07D333/70

CPC分类号： C07D333/70 ,  A61P19/06 ,  C07D495/04

摘要： A class of xanthine oxidase (XO) inhibitors, and application thereof in the preparation of drugs for treating XO-related diseases. Specifically disclosed is a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.

公开(公告)号：US20230174487A1

公开(公告)日：2023-06-08

申请号：US17922188

申请日：2021-04-30

申请人： MEDSHINE DISCOVERY INC.

发明人： Yang ZHANG ,  Wentao WU ,  Zhixiang LI ,  Wenyuan ZHU ,  Jian QIN ,  Shuhui CHEN

IPC分类号： C07D211/58 ,  C07D471/10 ,  C07D487/04

CPC分类号： C07D211/58 ,  C07D471/10 ,  C07D487/04

摘要： The use of a phenylpropionamide compound in the preparation of a drug for treating diseases associated with pain and pruritus. Specifically, the present invention relates to a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240140962A1

公开(公告)日：2024-05-02

申请号：US18276226

申请日：2022-01-26

申请人： MEDSHINE DISCOVERY INC.

发明人： Yangyang XU ,  Wentao WU ,  Haizhong TAN ,  Dongkai ZAHNG ,  Jikui SUN ,  Yang ZHANG ,  Shuhui CHEN

IPC分类号： C07D495/04 ,  A61P35/00 ,  C07D519/00

CPC分类号： C07D495/04 ,  A61P35/00 ,  C07D519/00

摘要： Provided are a series of 5,6-dihydrothieno[3,4-h]quinazoline compounds as represented by formula (P) and pharmaceutically acceptable salts thereof, and the use of the compounds or pharmaceutically acceptable salts thereof in the preparation of solid tumor drugs, such as solid tumor drugs associated with selective PLK1 inhibitors.

公开(公告)号：US20190202838A1

公开(公告)日：2019-07-04

申请号：US16323074

申请日：2017-08-08

申请人： MEDSHINE DISCOVERY INC.

发明人： Jian XIONG ,  Jingjing WANG ,  Wentao WU ,  Haizhong TAN ,  Xuanjia PENG ,  Yang ZHANG ,  Kevin X. CHEN ,  Jian LI ,  Shuhui CHEN

IPC分类号： C07D495/04 ,  A61P31/22

CPC分类号： C07D495/04 ,  A61K31/519 ,  A61P31/22

摘要： Disclosed are a class of fused cyclic compounds against the HCMV virus, and use thereof in the preparation of a drugs for treating diseases associated with the HCMV virus. In particular, disclosed is the compound shown in formula (II) and pharmaceutically acceptable salts thereof.