公开(公告)号：US20150038703A1

公开(公告)日：2015-02-05

申请号：US14517614

申请日：2014-10-17

申请人： MEI Pharma, Inc.

发明人： Ken Chi Lik Lee ,  Eric T. Sun ,  Haishan Wang

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  A61K31/44 ,  C07D491/02 ,  C07D498/02 ,  Y02A50/409 ,  Y02A50/411

摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).

摘要翻译： 本发明涉及作为组蛋白脱乙酰酶抑制剂的异羟肟酸酯化合物。 更具体地，本发明涉及含咪唑并[1,2-a]吡啶的化合物及其制备方法。 这些化合物可用作治疗增殖性疾病的药物以及涉及与组蛋白脱乙酰酶活性（HDAC）的酶有关或与之有关的其它疾病。

公开(公告)号：US09266882B2

公开(公告)日：2016-02-23

申请号：US14517614

申请日：2014-10-17

申请人： MEI Pharma, Inc.

发明人： Ken Chi Lik Lee ,  Eric T. Sun ,  Haishan Wang

IPC分类号： A61K31/44 ,  C07D498/02 ,  C07D491/02 ,  C07D471/04

CPC分类号： C07D471/04 ,  A61K31/44 ,  C07D491/02 ,  C07D498/02 ,  Y02A50/409 ,  Y02A50/411

摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).

摘要翻译： 本发明涉及作为组蛋白脱乙酰酶抑制剂的异羟肟酸酯化合物。 更具体地，本发明涉及含咪唑并[1,2-a]吡啶的化合物及其制备方法。 这些化合物可用作治疗增殖性疾病的药物以及涉及与组蛋白脱乙酰酶活性（HDAC）的酶有关或与之有关的其它疾病。

公开(公告)号：US08901149B2

公开(公告)日：2014-12-02

申请号：US14147290

申请日：2014-01-03

申请人： MEI Pharma, Inc.

发明人： Ken Chi Lik Lee ,  Eric T. Sun ,  Haishan Wang

IPC分类号： C07D471/04 ,  A61K31/44 ,  C07D498/02 ,  C07D491/02

CPC分类号： C07D471/04 ,  A61K31/44 ,  C07D491/02 ,  C07D498/02 ,  Y02A50/409 ,  Y02A50/411

摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).

摘要翻译： 本发明涉及作为组蛋白脱乙酰酶抑制剂的异羟肟酸酯化合物。 更具体地，本发明涉及含咪唑并[1,2-a]吡啶的化合物及其制备方法。 这些化合物可用作治疗增殖性疾病的药物以及涉及与组蛋白脱乙酰酶活性（HDAC）的酶有关或与之有关的其它疾病。

公开(公告)号：US20140121203A1

公开(公告)日：2014-05-01

申请号：US14147290

申请日：2014-01-03

申请人： MEI Pharma, Inc.

发明人： Ken Chi Lik Lee ,  Eric T. Sun ,  Haishan Wang

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  A61K31/44 ,  C07D491/02 ,  C07D498/02 ,  Y02A50/409 ,  Y02A50/411

摘要： The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to imidazo[1,2-a]pyridine containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase activities (HDAC).

摘要翻译： 本发明涉及作为组蛋白脱乙酰酶抑制剂的异羟肟酸酯化合物。 更具体地，本发明涉及含咪唑并[1,2-a]吡啶的化合物及其制备方法。 这些化合物可用作治疗增殖性疾病的药物以及涉及与组蛋白脱乙酰酶活性（HDAC）的酶有关或与之有关的其它疾病。