公开(公告)号：US20230391758A1

公开(公告)日：2023-12-07

申请号：US18043413

申请日：2021-09-15

申请人： MERCK SHARP & DOHME CORP.

发明人： Michael J. Breslin ,  Mark E. Fraley ,  Melissa C. Ford ,  Kristen L.G. Jones, SR. ,  Anthony J. Roecker ,  Kathy M. Schirripa ,  Ling Tong

IPC分类号： C07D405/12 ,  C07D471/04 ,  C07D307/85 ,  C07D405/06 ,  C07D453/02 ,  C07D405/14 ,  C07D413/12

CPC分类号： C07D405/12 ,  C07D471/04 ,  C07D307/85 ,  C07D405/06 ,  C07D453/02 ,  C07D405/14 ,  C07D413/12

摘要： The present invention relates to Compounds of Formula I: and pharmaccutically acceptable salts or prodrug thereof. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treatment or prophylaxis of lysosomal storage diseases, neurodegenerative disease, cystic disease, cancer, or a diseases or disorders associated with elevated levels of glucosylceramide (GlcCer), glucosylsphingosine (GlcSph) and/or other glucosylceramide-based glycosphingolipids (GSLs).