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公开(公告)号:US10117836B2
公开(公告)日:2018-11-06
申请号:US15115026
申请日:2015-01-30
发明人: Mary Ann Johnson , Leonardo Resende Allain , W. Mark Eickhoff , Craig B. Ikeda , Chad D. Brown , Francis J. Flanagan, Jr. , Rebecca Nofsinger , Melanie Marota , Lisa Lupton , Paresh B. Patel , Hanmi Xi , Wei Xu
IPC分类号: A61K31/437 , A61K31/4545 , A61K9/20
摘要: The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): Formula I, wherein “Ra” is independently H or —F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.
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公开(公告)号:US20210085612A1
公开(公告)日:2021-03-25
申请号:US17110398
申请日:2020-12-03
发明人: Mary Ann Johnson , Leonardo Resende Allain , W. Mark Eickhoff , Craig B. Ikeda , Chad D. Brown , Francis J. Flanagan, JR. , Rebecca Nofsinger , Melanie Marota , Lisa Lupton , Paresh B. Patel , Hanmi Xi , Wei Xu
IPC分类号: A61K9/20 , A61K31/437 , A61K31/4545
摘要: The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): wherein “Ra” is independently —H or —F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.
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公开(公告)号:US20160346214A1
公开(公告)日:2016-12-01
申请号:US15115026
申请日:2015-01-30
发明人: Mary Ann Johnson , Leonardo Resende Allain , W. Mark Eickhoff , Craig B. Ikeda , Chad D. Brown , Francis J. Flanagan, JR. , Rebecca Nofsinger , Melanie Marota , Lisa Lupton , Paresh B. Patel , Hanmi Xi , Wei Xu
IPC分类号: A61K9/20 , A61K31/4545
CPC分类号: A61K9/2077 , A61K9/146 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K31/437 , A61K31/4545
摘要: The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): Formula I, wherein “Ra” is independently H or —F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.
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公开(公告)号:US20190209478A1
公开(公告)日:2019-07-11
申请号:US16178641
申请日:2018-11-02
发明人: Mary Ann Johnson , Leonardo Resende Allain , W. Mark Eickhoff , Craig B. Ikeda , Chad D. Brown , Francis J. Flanagan, JR. , Rebecca Nofsinger , Melanie Marota , Lisa Lupton , Paresh B. Patel , Hanmi Xi , Wei Xu
IPC分类号: A61K9/20 , A61K31/4545 , A61K31/437
CPC分类号: A61K9/2077 , A61K9/146 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K31/437 , A61K31/4545
摘要: The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): wherein “Ra” is independently —H or —F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.
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