专利检索 ap:("MERCK SHARP & DOHME CORP." OR "MERCK SHARP & DOHME LIMITED") AND inv:"Feng Yu" 第 1 页

1.

发明申请
METHODS OF PREPARING HYDROXYLAMINE DERIVATIVES USEFUL IN THE PREPARATION OF ANTI-INFECTIVE AGENTS 审中-公开

公开(公告)号：US20190055216A1

公开(公告)日：2019-02-21

申请号：US16074141

申请日：2017-01-30

申请人： MERCK SHARP & DOHME CORP. , MERCK SHARP & DOHME LIMITED

发明人： Aaron M. Dumas , Jeremy P. Scott , Michael Shevlin , Zhijian Liu , John Y. L. Chung , Feng Yu , Dongfang Meng

IPC分类号： C07D401/12 , C07D211/78 , C07C249/08 , C07C251/38

摘要： The present invention relates to processes for the preparation of N-protected 4-((2S,5R)-5-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylates. Such compounds have application in the preparation of beta-lactamase inhibitors such as 7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamides and esters, in particular, the beta lactamase inhibitor, (2S,5R)-7-oxo-N-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide. The present invention also encompasses intermediates useful in the disclosed processes and methods for their preparation.