公开(公告)号：US20240043491A1

公开(公告)日：2024-02-08

申请号：US18258397

申请日：2021-12-21

申请人： MERCK SHARP & DOHME LLC

发明人： Stephen E. ALVES ,  Glareh AZADI ,  Maribel BEAUMONT ,  Lia BENSO ,  Alan C. CHENG ,  Peter GEORGIEV ,  Brian E. HALL ,  Veronica M. JUAN ,  Renee MOORE ,  Venkataraman SRIRAMAN ,  Jie ZHANG-HOOVER

IPC分类号： C07K14/55

CPC分类号： C07K14/55 ,  A61K38/00

摘要： Provided herein are IL-2 muteins that bind to IL-2 receptor subunit but do not have measurable binding to IL-2 receptor subunit. Also provided are compositions, kits, methods, and uses involving such IL-2 muteins.