公开(公告)号：US20220033352A1

公开(公告)日：2022-02-03

申请号：US17279326

申请日：2019-09-26

申请人： MEREO BIOPHARMA 1 LIMITED

发明人： Mark MEISENBACH ,  Benjamin MARTIN ,  Niek Johannes RONDE

IPC分类号： C07C253/30 ,  B01D3/00 ,  B01D3/10 ,  C07C253/34

摘要： Provided is a process for preparing a compound of Formula A (Formula A) or a salt or solvate thereof, the process comprising the step of: a) Reacting the compound 1 (1) with a trialkyl orthoformate to provide a compound of Formula A or a salt or solvate thereof, wherein R is the alkyl moiety of the trialkyl orthoformate. Further provided is the compound 2 or a salt or solvate thereof. (2) The use of these compounds in the synthesis of 3-[5-Amino-4-(3-Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide is also provided.

公开(公告)号：US20210395207A1

公开(公告)日：2021-12-23

申请号：US17279553

申请日：2019-09-26

申请人： MEREO BIOPHARMA 1 LIMITED

发明人： Mark MEISENBACH ,  Benjamin MARTIN ,  Niek Johannes RONDE ,  Carmen RUIZ

IPC分类号： C07D231/38

摘要： Provided is a process for preparing a compound, comprising the steps of a) Reacting a compound of Formula A (Formula A) with the compound 3 (3) to provide the compound 5 (5) or a salt or solvate thereof, wherein R is a linear or branched C1-C5 alkyl. Further provided is the compound 5 or a salt or solvate thereof. (5) The use of these compounds in the synthesis of 3-[5-Amino-4-(3-Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide is also provided.