公开(公告)号：US20210206726A1

公开(公告)日：2021-07-08

申请号：US17149649

申请日：2021-01-14

申请人： MEREO BIOPHARMA 1 LIMITED

发明人： Osama SULEIMAN ,  Lucia Romero PEREZ ,  Cornelius Stephan HARLACHER ,  Stewart JONES

IPC分类号： C07D231/18

摘要： This invention relates to a process for the preparation of Form A of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide. Also disclosed herein is Form A of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide, or pharmaceutical compositions thereof, obtainable by the process described herein.

公开(公告)号：US20190315694A1

公开(公告)日：2019-10-17

申请号：US16317014

申请日：2017-07-13

申请人： MEREO BIOPHARMA 1 LIMITED

发明人： Osama SULEIMAN ,  Lucia Romero PEREZ ,  Cornelius Stephan HARLACHER ,  Stewart JONES

IPC分类号： C07D231/38

摘要： This invention relates to a process for the preparation of Form B of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide. Also disclosed herein is Form B of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide, or pharmaceutical compositions thereof, obtainable by the process described herein.

公开(公告)号：US20190352269A1

公开(公告)日：2019-11-21

申请号：US16317012

申请日：2017-07-13

申请人： MEREO BIOPHARMA 1 LIMITED

发明人： Osama SULEIMAN ,  Lucia Romero PEREZ ,  Cornelius Stephan HARLACHER ,  Stewart JONES

IPC分类号： C07D231/18

摘要： This invention relates to a process for the preparation of Form A of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide. Also disclosed herein is Form A of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide, or pharmaceutical compositions thereof, obtainable by the process described herein.