公开(公告)号：US11434204B2

公开(公告)日：2022-09-06

申请号：US17149649

申请日：2021-01-14

申请人： MEREO BIOPHARMA 1 LIMITED

发明人： Osama Suleiman ,  Lucia Romero Perez ,  Cornelius Stephan Harlacher ,  Stewart Jones

IPC分类号： C07D231/18

摘要： This invention relates to a process for the preparation of Form A of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide. Also disclosed herein is Form A of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide, or pharmaceutical compositions thereof, obtainable by the process described herein.

公开(公告)号：US10934260B2

公开(公告)日：2021-03-02

申请号：US16317012

申请日：2017-07-13

申请人： MEREO BIOPHARMA 1 LIMITED

发明人： Osama Suleiman ,  Lucia Romero Perez ,  Cornelius Stephan Harlacher ,  Stewart Jones

IPC分类号： C07D231/18

摘要： This invention relates to a process for the preparation of Form A of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide. Also disclosed herein is Form A of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide, or pharmaceutical compositions thereof, obtainable by the process described herein.

公开(公告)号：US10995071B2

公开(公告)日：2021-05-04

申请号：US16317014

申请日：2017-07-13

申请人： MEREO BIOPHARMA 1 LIMITED

发明人： Osama Suleiman ,  Lucia Romero Perez ,  Cornelius Stephan Harlacher ,  Stewart Jones

IPC分类号： C07D231/38

摘要： This invention relates to a process for the preparation of Form B of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide. Also disclosed herein is Form B of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide, or pharmaceutical compositions thereof, obtainable by the process described herein.