公开(公告)号：US20170290895A1

公开(公告)日：2017-10-12

申请号：US15480345

申请日：2017-04-05

Applicant: MERIAL INC.

Inventor： Laurent Fischer

IPC: A61K39/00 ,  C07K16/20

CPC classification number: A61K39/0003 ,  A61K39/0233 ,  C07K14/43536 ,  C07K14/4354 ,  C07K16/20

Abstract: The present invention encompasses a vaccine composition and method of use for treating heartworm infestation in mammals. The vaccine composition includes chimeric antigens engineered and manufactured using the genetic code (i.e., the amino acid or protein sequence) of the target sequence. After introduction of the vaccine composition containing the target antigen into the host (e.g., a canine), the host will generate antibodies as part of its robust immune response to the antigen. As the antibodies circulate through the host's plasma, heartworm larvae will consume the antibodies as they feed on the plasma. The antibodies will then act on internal targets of the worm recognized as antigens.