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公开(公告)号：US11801267B2
公开(公告)日：2023-10-31
申请号：US16106723
申请日：2018-08-21
Applicant: METCELA INC.
Inventor： Takahiro Iwamiya , Katsuhisa Matsuura
CPC classification number: A61K35/33 , A61K38/1774 , C12N1/00 , C12N5/0656 , C12N5/0657 , C12N5/10 , C12N2501/58 , C12N2502/1323 , C12N2502/1329
Abstract: The purpose of the present invention is to provide a cardiac cell culture material which specifically acts on cardiac cells. In addition, another purpose of the present invention is to provide artificial organ material obtained by culturing by using said cardiac cell culture material, and a method for producing the same. Thus, provided is a cardiac cell culture, wherein functional cardiac tissue is favorably built by using a cardiac cell culture material containing VCAM-1.
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公开(公告)号：US20240316113A1
公开(公告)日：2024-09-26
申请号：US18577841
申请日：2022-08-23
Applicant: METCELA INC.
Inventor： Takahiro Iwamiya , Jun Homma , Tomomi Imamura , Yuimi Matsuoka
Abstract: Based on the discovery that fibroblasts suppress renal fibrosis to recover the renal function in a rat model with a kidney disease, a pharmaceutical composition for treatment of a kidney disease, the composition including fibroblasts, was successfully provided.
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公开(公告)号：US11096969B2
公开(公告)日：2021-08-24
申请号：US16263321
申请日：2019-01-31
Applicant: METCELA INC.
Inventor： Takahiro Iwamiya
Abstract: The present invention aims to provide a method which has not been established yet and which is useful for achieving long-term and fundamental cure of a necrotic cardiac tissue region to allow recovery of functionality of the heart.
The present invention provides an injectable composition for treatment of a cardiac disease, the composition comprising fibroblasts, wherein the fibroblasts contain CD106-positive fibroblasts, preferably contain CD90-positive fibroblasts, and the fibroblasts do not form colonies.
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