公开(公告)号：US3798324A

公开(公告)日：1974-03-19

申请号：US3798324D

申请日：1972-12-21

Applicant: MILES LAB

Inventor： RODRIGUEZ R

IPC: A61K31/495 ,  A61K27/00

CPC classification number: A61K31/495

Abstract: ADMINISTRATION OF AN EFFECTIVE AMOUNT OF 1-(2-PYRIDYL) PIPERAZINE OR A NONTOXIC ACID ADDITION SALT THEREOF CONTROLS TREMOR SYMPTOMATIC OR PARKINSONISM IN MAMMALS. DAILY DOES RANGING FROM 10 MG./KG. TO 90 MG./KG. ARE CONSIDERED EFFECTIVE.

公开(公告)号：US3743732A

公开(公告)日：1973-07-03

申请号：US3743732D

申请日：1972-02-14

Applicant: MILES LAB

Inventor： RODRIGUEZ R

IPC: C07D215/38 ,  A61K27/00

CPC classification number: C07D215/38

Abstract: THE TREMOR OF PARKINSONS''S SYNDROME IN MAMMALS IS SUPPRESSED BY THE ADMINSTRATION OF A COMPIUND OF THE FORMULA:

2-(4-R-PIPERAZIN-1-YL)-QUINOLINE

IN WHICH R IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF H AND CH3, AND NONTOXIC PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF. THESE COMPOUNDS MAY BE UTILIZED IN CONJUNCTION WITH PHARMACEUTICALLY ACCEPTABLE VEHICLES THEREFOR.

公开(公告)号：US3790674A

公开(公告)日：1974-02-05

申请号：US3790674D

申请日：1972-12-21

Applicant: MILES LAB

Inventor： RODRIGUEZ R

IPC: A61K31/495 ,  A61K27/00

CPC classification number: A61K31/495 ,  A61K31/135

Abstract: A COMPOSITION COMPRISING 1-(2-PYRIDYL)PIPERAZINE AND LEVODOPA IN A RESPECTIVE WEIGHT RATIO OF FROM 1:320 TO 1:20 CONTROLS TREMO SYMPTOMATIC OF PARKINSONISM IN MAMMALS. PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS OF 1-(2-PYRIDYL) PIPERAZINE CAN BE SUBSTITUTED IN LIEU OF THE PARENT COMPOUND IN THE COMPOSITION.

公开(公告)号：US3737540A

公开(公告)日：1973-06-05

申请号：US3737540D

申请日：1972-02-14

Applicant: MILES LAB

Inventor： RODRIGUEZ R

IPC: A61K31/495 ,  C07D215/38 ,  A61K27/00

CPC classification number: C07D215/38 ,  A61K31/495 ,  A61K31/195 ,  A61K2300/00

Abstract: THE TREMOR OF PARKINSON''S SYNDRONE IN MAMMALS IS SUPPRESSED BY THE ADMINISTRATION OF A COMPOSITION COMPRISING (1) A COMPOUND OF THE FORMULA

2-(4-R-PIPERAZIN-1-YL)-QUINOLINE

IN WHICH R IS EITHER H OR CH3, AND NONTOXIC PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, AND (2) L-3,4-DIHYDROXYPHENYLALANINE.

公开(公告)号：US3773951A

公开(公告)日：1973-11-20

申请号：US3773951D

申请日：1972-12-21

Applicant: MILES LAB

Inventor： RODRIGUEZ R

IPC: A61K31/495 ,  A61K27/00

CPC classification number: A61K31/495

Abstract: ADMINISTRATION OF 1-(2-PYRIDYL)PIPERAZINE OR A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF IS DISCLOSED AS A CHEMOTHERAPEUTIC METHOD OF TREATING MANIFESTATIONS OF DEPRESSION IN EXPERIMENTAL MAMMALS. DAILY DOSES RANGING FROM 2 MG./KG. TO 60 MG./KG. PER DAY ARE CONSIDERED EFFECTIVE.