公开(公告)号：US20240189242A1

公开(公告)日：2024-06-13

申请号：US18277346

申请日：2022-02-18

Applicant: MODERNATX, INC.

Inventor： Meredith PACKER ,  Dipendra GYAWALI ,  Serenus HUA ,  Gabor BUTORA ,  Gregory John MERCER

IPC: A61K9/51 ,  A61K31/7105 ,  A61K47/18 ,  A61K47/26

CPC classification number: A61K9/5123 ,  A61K31/7105 ,  A61K47/18 ,  A61K47/26

Abstract: Provided herein are methods of reducing adduct formation in lipid nanoparticle compositions comprising a polynucleotide, such as mRNA, and an ionizable lipid; also disclosed are lipid nanoparticle compositions having a reduced adduct content, and methods of detecting the adducts.