公开(公告)号：US20250041393A1

公开(公告)日：2025-02-06

申请号：US18706652

申请日：2022-11-01

Applicant: MODERNATX, INC.

Inventor： Eric Yi-Chun Huang ,  Paul Stein ,  Laurie Kenney ,  Michelle Dutra ,  Myoungjoo Kim ,  Pranitha Vangala

IPC: A61K39/00 ,  A61K9/127 ,  A61K9/51 ,  A61P37/06 ,  G01N33/50

Abstract: The disclosure features lipid nanoparticle (LNP) compositions ITB6 molecules and uses thereof. The LNP compositions of the present disclosure comprise mRNA therapeutics encoding ITB6 polypeptides. The LNP compositions of the present disclosure can reprogram dendritic cells, suppress T cells and/or induce immune tolerance in vivo.