公开(公告)号：US20220411382A1

公开(公告)日：2022-12-29

申请号：US17755412

申请日：2020-03-10

Applicant: MOEHS IBERICA, S.L.

Inventor： Roberto BALLETTE ,  Oscar JIMÉNEZ ALONSO ,  Elena GARCÍA GARCÍA ,  Alicia DOBARRO RODRÍGUEZ

IPC: C07D239/553 ,  C07D239/557

Abstract: A new intermediate is useful in the synthesis of elagolix. A process for obtaining the intermediate includes reacting a precursor with iodine monochloride in the presence of an organic solvent. A process for preparing elagolix makes use of the intermediate. The intermediate can be 3-((R)-2-(amino-2-phenylethyl)-1-(2-fluoro-6-trifluoromethylbenzyl)-5-iodo-6-methyl-1H-pyrimidine-2,4-dione or a salt thereof, such as a hydrochloride.