公开(公告)号：US20180207246A1

公开(公告)日：2018-07-26

申请号：US15927390

申请日：2018-03-21

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： DAN ABRAHAMOV

IPC: A61K38/57 ,  A61K45/06 ,  A61K9/00

CPC classification number: A61K38/57 ,  A61K9/0019 ,  A61K45/06

Abstract: A method for preventing bleeding, blood-brain barrier disruption, brain injury, or a combination thereof in a subject destined for cardiac surgery is disclosed. The method involves administering to the subject prior to cardiac surgery a therapeutically effective amount of alpha-1 antitrypsin (AAT-1), or functional variant thereof. The result is that it prevents bleeding, blood-brain barrier disruption, or a combination thereof in a subject destined for cardiac surgery.