公开(公告)号：US20130190275A1

公开(公告)日：2013-07-25

申请号：US13733130

申请日：2013-01-02

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Shlomo Mendlovic ,  Yechiel Levkovitz

IPC: A61K31/65 ,  A61K45/06 ,  A61K31/4515

CPC classification number: A61K31/65 ,  A61K31/4515 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides combinations of an antipsychotic drug and a tetracycline, particularly minocycline, for the treatment of psychotic disorders, particularly schizophrenia. The invention also provides formulations wherein the release of one or both of the antipsychotic drug and the tetracycline is modified. The invention also provides methods using the combined therapy for treatment of psychotic disorders, particularly schizophrenia, comprising an antipsychotic drug and a tetracycline.

Abstract translation: 本发明提供了用于治疗精神病性疾病，特别是精神分裂症的抗精神病药物和四环素，特别是二甲胺四环素的组合。 本发明还提供其中修饰了抗精神病药物和四环素中的一种或两种的释放的制剂。 本发明还提供了使用组合疗法治疗精神病，特别是精神分裂症的方法，其包括抗精神病药和四环素。