公开(公告)号：US20210206834A1

公开(公告)日：2021-07-08

申请号：US17154864

申请日：2021-01-21

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Dov WEINBERGER ,  Tami LIVNAT ,  Yael NISGAV

IPC: C07K14/745 ,  A61P27/02 ,  A61K45/06

Abstract: Methods for treating and/or preventing choroidal neovascularization (CNV) or retinal leakage associated with CNV are disclosed, comprising the use of activated protein C (APC) and/or an APC variant. A disclosed method may be applied in the treatment or prevention of ocular diseases, disorders or conditions that are caused directly by CVN, feature development of CNV as a secondary stage or a complication thereof, and/or feature CNV as a synchronous or asynchronous sequela thereof. An exemplary disease treatable by a disclosed method is neovascular age-related macular degeneration (nAMD).