公开(公告)号：US10206900B2

公开(公告)日：2019-02-19

申请号：US15083370

申请日：2016-03-29

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Ayala Pollack ,  Zeev Dvashi

IPC: A61K31/335 ,  C07K16/40

Abstract: Disclosed herein are methods for treatment for fibrosis, ocular pathologies associated with fibrosis, including proliferative vitreoretinopathy (PVR) by inhibiting the activity of activated transforming growth factor β activated kinase 1 (TAK1), or activation thereof. Pharmaceutical compositions for use in the described treatments are also provided.

公开(公告)号：US09878021B2

公开(公告)日：2018-01-30

申请号：US14894347

申请日：2014-05-29

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Ayala Pollack ,  Zeev Dvashi

IPC: A61K31/40 ,  A61K38/17 ,  A61K38/45

CPC classification number: A61K38/45 ,  A61K31/40 ,  A61K38/1709 ,  C12Y207/11025

Abstract: This disclosure relates to compositions for use in treatment of a retinal degenerative disease, such as age related macular degeneration. The described compositions include agents for activating p38 and/or JNK signaling through the activation of TAK1 in the retinal pigment epithelium of a subject diagnosed with the disease. Methods of treatment of a retinal degenerative disease using the described compositions are also provided.

公开(公告)号：US20160206591A1

公开(公告)日：2016-07-21

申请号：US15083370

申请日：2016-03-29

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Ayala Pollack ,  Zeev Dvashi

IPC: A61K31/335 ,  C07K16/40

CPC classification number: A61K31/335 ,  A61K31/365 ,  C07K16/40

Abstract: Disclosed herein are methods for treatment for fibrosis, ocular pathologies associated with fibrosis, including proliferative vitreoretinopathy (PVR) by inhibiting the activity of activated transforming growth factor β activated kinase 1 (TAK1), or activation thereof. Pharmaceutical compositions for use in the described treatments are also provided.

Abstract translation: 本文公开了通过抑制活化的转化生长因子和活性的活性来治疗纤维化，与纤维化相关的眼部病理学的方法，包括增殖性玻璃体视网膜病变（PVR） 活化激酶1（TAK1）或其活化。 还提供了用于所述治疗的药物组合物。

公开(公告)号：US10682328B2

公开(公告)日：2020-06-16

申请号：US15532116

申请日：2015-12-03

Applicant: MOR RESEARCH APPLICATIONS LTD.

Inventor： Zeev Dvashi ,  Ayala Pollack

IPC: A61K31/223 ,  A61K31/40 ,  A61K9/00 ,  A61K45/06 ,  A61K38/05 ,  A61P25/28 ,  A61P27/02

Abstract: This disclosure relates to compositions for use in treatment of Alzheimer's Disease, and/or a ocular and retinal degenerative disease, such as age related macular degeneration. The described compositions include effective amounts of LLMe, the hydrobromide form thereof, or functional derivatives thereof. Methods of treatment of a retinal degenerative disease of Alzheimer's Disease using the described compositions are also provided.