公开(公告)号：US11519914B2

公开(公告)日：2022-12-06

申请号：US16480342

申请日：2018-01-25

申请人： MOR RESEARCH APPLICATIONS LTD. ,  RAMOT AT TEL AVIV UNIVERSITY LTD.

发明人： Esther Rabizadeh

IPC分类号： G01N33/86 ,  G01N33/574

摘要： A method for diagnosing a malignant proliferative disease or disorder in a subject, and/or for following up, monitoring or prognosticating the therapy of a malignant proliferative disease or disorder in a subject is disclosed. The method is based on measurement of platelet-mediated fibrinogen-like protein 2 (FGL2) activity in a sample essentially comprising platelets obtained from the subject. In accordance with the disclosed method, platelet-mediated FGL2 activity level higher than control is indicative of the presence of a malignant proliferative disease or disorder in a subject.