公开(公告)号：US20200377594A1

公开(公告)日：2020-12-03

申请号：US16635303

申请日：2018-08-13

Applicant: MORPHOSYS AG

Inventor： Thomas TILLER ,  Steffen RUNZ ,  Julia NEUGEBAUER ,  Andreas BÜLTMANN

IPC: C07K16/28 ,  C07K16/32

Abstract: The present disclosure provides humanized antibodies that specifically bind to CD3 with an optimized affinity and induce T cell-mediated killing of tumour related target antigen high expressing cells with high potency but have limited killing activity on target antigen low expressing cells. The present disclosure also provides bispecific antibodies comprising a first antigen-binding domain that specifically binds to human CD3 with optimized affinity and a second antigen-binding molecule that specifically binds a tumor-related antigen. The disclosure further relates to methods of generating such humanized antibodies and bispecific antibodies for biological, diagnostic, pharmaceutical and other uses.

公开(公告)号：US20220135660A1

公开(公告)日：2022-05-05

申请号：US17571794

申请日：2022-01-10

Applicant: MorphoSys AG

Inventor： Julia NEUGEBAUER ,  Steffen RUNZ ,  Stefanie URLINGER

IPC: C07K16/18

Abstract: The disclosure relates to novel Fab molecules comprising a modified heavy chain constant region. The modified constant region prevents the recognition of the Fab molecules by anti-Fab antibodies present in a host's serum. The disclosure further relates to methods of generating such modified Fab molecules for biological, diagnostic, pharmaceutical and other uses.

公开(公告)号：US20230357398A1

公开(公告)日：2023-11-09

申请号：US18246052

申请日：2021-09-22

Applicant: MORPHOSYS AG

Inventor： Andreas BÜLTMANN ,  Steffen RUNZ ,  Tschimegma BATAA ,  Markus MOOSMEIER ,  Nicole HAUBST ,  Jürgen KLATTIG ,  Yvonne STARK

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2809 ,  A61P35/00 ,  C07K2317/565 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/55 ,  C07K2317/31

Abstract: The present disclosure provides novel fully human antibodies and antibody fragments specific for human CD3 epsilon.

公开(公告)号：US20210214435A1

公开(公告)日：2021-07-15

申请号：US17055528

申请日：2019-05-15

Applicant: MORPHOSYS AG

Inventor： Kerstin UHLAND ,  Julia NEUGEBAUER ,  Steffen RUNZ

IPC: C07K16/28 ,  A61P7/02

Abstract: The present disclosure provides antibodies or antibody fragments specific for GPVI. In particular, it relates to antibodies or antibody fragments that have combined beneficial properties and are therefore useful for the treatment or prophylaxis of GPVI related disorders or conditions, such as for example thrombotic or vascular disorders.