公开(公告)号：US20220144965A1

公开(公告)日：2022-05-12

申请号：US17434465

申请日：2020-03-13

Applicant: MORPHOSYS AG

Inventor： Daniel KLUNKER ,  Rainer BOXHAMMER ,  Stefan HÄRTLE ,  Stefan STEIDL ,  Tiantom JARUTAT

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61P37/06

Abstract: The present invention relates to the use of an antibody or antibody fragment specific for CD38 in the prophylaxis and/or treatment of autoantibody-mediated autoimmune disease. In accordance with the present invention, an anti-CD38 antibody is effective in the treatment of anti-PLA2R positive membranous glomerulonephropathy.