公开(公告)号：US20180338963A1

公开(公告)日：2018-11-29

申请号：US15745913

申请日：2016-06-24

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Satish NADIG ,  Carl ATKINSON ,  Ann-Marie BROOME ,  Suraj K. DIXIT

IPC: A61K31/453 ,  A61K31/343 ,  A61K38/13 ,  A61K47/10 ,  A61K47/18 ,  A61K9/107 ,  A61K9/127 ,  A61K9/51 ,  A61K38/20 ,  A61P37/06

Abstract: Provided herein is a formulation to pre-treat an organ prior to transplantation, comprising a therapeutically effective amount of an immunosuppressive agent encapsulated in a micelle, liposome or polymeric nanoparticle that comprises on its surface a targeting moiety.