公开(公告)号：US20190247478A1

公开(公告)日：2019-08-15

申请号：US16342853

申请日：2017-10-17

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Stephen TOMLINSON ,  DeAnna ADKINS ,  Ali ALAWIEH

IPC: A61K38/57 ,  A61K38/17 ,  A61P25/00 ,  C07K16/18

CPC classification number: A61K38/57 ,  A61K38/1709 ,  A61K38/1725 ,  A61K38/49 ,  A61K2039/505 ,  A61P25/00 ,  C07K16/18 ,  C07K2317/622 ,  A61K2300/00

Abstract: The present invention describes compositions and method for improving outcomes after injury to the central nervous system wherein complement signaling is activated. In one aspect, the method comprises administering to a subject a therapeutically effective amount of a therapeutic agent comprising a targeted inhibitor molecule comprising a targeting portion and an inhibitor portion, wherein the molecule inhibits complement, and wherein therapeutic agent is administered in combination with rehabilitation therapy or thrombolytic agent.