公开(公告)号：US11260027B2

公开(公告)日：2022-03-01

申请号：US15745913

申请日：2016-06-24

Applicant: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT

Inventor： Satish Nadig ,  Carl Atkinson ,  Ann-Marie Broome ,  Suraj K. Dixit

IPC: A61K9/107 ,  A61K9/127 ,  A61K38/13 ,  A61K9/51 ,  A01N1/02 ,  A61K31/436 ,  A61K31/365 ,  A61K38/20 ,  A61K31/713 ,  A61P37/06 ,  A61K31/343 ,  A61K47/10 ,  A61K31/453 ,  B82Y5/00

Abstract: Provided herein is a formulation to pre-treat an organ prior to transplantation, comprising a therapeutically effective amount of an immunosuppressive agent encapsulated in a micelle, liposome or polymeric nanoparticle that comprises on its surface a targeting moiety.