公开(公告)号：US20130317123A1

公开(公告)日：2013-11-28

申请号：US13849394

申请日：2013-03-22

Applicant: MYRIAD GENETICS, INC.

Inventor： Karla Bowles ,  Benoit Leclair ,  Saradha Rajamani ,  Jeffrey T. Trost ,  Jack W. Landon ,  Benjamin B. Roa

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/156

Abstract: Large deletions have been identified in the PMS2 gene in patients. The large deletions predispose the patients to Lynch syndrome associated cancers.

Abstract translation: 患者PMS2基因中已经发现大量缺失。 这种大的缺失使患者易患Lynch综合征相关癌症。

公开(公告)号：US20130252826A1

公开(公告)日：2013-09-26

申请号：US13849373

申请日：2013-03-22

Applicant: MYRIAD GENETICS, INC.

Inventor： Karla Bowles ,  Benoit Leclair ,  Saradha Rajamani ,  Jeffrey T. Trost ,  Jack W. Landon ,  Benjamin B. Roa

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/156

Abstract: Large deletions have been identified in the PMS2 gene in patients. The large deletions predispose the patients to Lynch syndrome associated cancers. Thus, methods for detecting the genetic variants are provided which can be used in detecting a predisposition to cancer.

Abstract translation: 患者PMS2基因中已经发现大量缺失。 这种大的缺失使患者易患Lynch综合征相关癌症。 因此，提供了用于检测遗传变体的方法，其可用于检测癌症的倾向。