公开(公告)号：US20160367546A1

公开(公告)日：2016-12-22

申请号：US14744042

申请日：2015-06-19

Applicant: Macau University of Science and Technology

Inventor： Xiao Jun YAO ,  Lai Han LEUNG ,  Lian Xiang LUO ,  Yan Ling ZHOU ,  Liang LIU

IPC: A61K31/4745

CPC classification number: A61K31/4745

Abstract: The present invention provides a compound that inhibits activity of oncogenic ROS1, a composition comprising said compound. The present invention also provides the use of said composition for treating cancer.

Abstract translation: 本发明提供抑制致癌ROS1活性的化合物，其是包含所述化合物的组合物。 本发明还提供了所述组合物用于治疗癌症的用途。

公开(公告)号：US20140371254A1

公开(公告)日：2014-12-18

申请号：US14285651

申请日：2014-05-23

Applicant: Macau University of Science and Technology

Inventor： Lai Han LEUNG ,  Xing Xing FAN ,  Liang LIU

IPC: A61K31/4741

CPC classification number: A61K31/4741

Abstract: The present invention discloses a method of preventing and treating Gefitinib-resistant non-small-cell lung cancer, comprising administering an effective amount of an alkaloid. A pharmaceutical composition comprising an alkaloid admixed with a pharmaceutical carrier for treating Gefitinib-resistant non-small-cell lung cancer is also disclosed therein.

Abstract translation: 本发明公开了一种预防和治疗吉非替尼抗性非小细胞肺癌的方法，包括给予有效量的生物碱。 还公开了包含与用于治疗吉非替尼非小细胞肺癌的药物载体混合的生物碱的药物组合物。