公开(公告)号：US4508658A

公开(公告)日：1985-04-02

申请号：US113380

申请日：1980-01-18

申请人： Magda Huhn ,  Gabor Szabo ,  Peter Dvortsak ,  Marianna Karpati ,  Eva Somfai

发明人： Magda Huhn ,  Gabor Szabo ,  Peter Dvortsak ,  Marianna Karpati ,  Eva Somfai

IPC分类号： C07C255/41 ,  C07C67/00 ,  C07C253/00 ,  C07C253/30 ,  C07C255/19 ,  C07C255/32 ,  C07D213/26 ,  C07D213/57 ,  C07D307/38 ,  C07D333/12 ,  C07D333/24 ,  C07C121/46

CPC分类号： C07C255/00

摘要： Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen or C.sub.1 to C.sub.6 alkyl;R.sup.2 is hydrogen, phenyl, thienyl, furyl, pyridyl, C.sub.1 to C.sub.6 alkyl, furylalkyl where the alkyl is C.sub.1 to C.sub.6, or phenylalkyl where the alkyl is C.sub.1 to C.sub.6 ; orR.sup.1 and R.sup.2 together form C.sub.1 to C.sub.4 alkylene, furyl-C.sub.1 to C.sub.4 alkylene or phenyl-C.sub.1 to C.sub.4 alkylene; and X is halo; ora pharmaceutically acceptable salt thereof, are disclosed as well as a process for the preparation thereof. The new compounds are intermediates useful in the production of penicillins and cephalosporins with antibiotic activity.

摘要翻译： 式IMA的化合物，其中R 1是氢或C 1 -C 6烷基; R2是氢，苯基，噻吩基，呋喃基，吡啶基，C1至C6烷基，其中烷基为C1至C6的呋喃基烷基，或烷基为C1至C6的苯基烷基; 或R 1和R 2一起形成C 1至C 4亚烷基，呋喃基-C 1至C 4亚烷基或苯基-C 1至C 4亚烷基; 且X为卤素; 或其药学上可接受的盐，以及其制备方法。 新化合物是可用于生产具有抗生素活性的青霉素和头孢菌素的中间体。