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    Bacterial cell surface protein with fibronectin, fibrinogen, collagen and laminin binding ability, process for the manufacture of the protein and prophylactic treatment
    2.
    发明授权
    Bacterial cell surface protein with fibronectin, fibrinogen, collagen and laminin binding ability, process for the manufacture of the protein and prophylactic treatment 失效
    具有纤连蛋白，纤维蛋白原，胶原和层粘连蛋白结合能力的细菌细胞表面蛋白，用于制造蛋白质和预防性治疗的方法

    公开(公告)号：US5980908A

    公开(公告)日：1999-11-09

    申请号：US118697

    申请日：1993-09-10

    申请人： Magnus Hook ,  Kjell Martin Lindberg ,  Torkel Mikael Wadstrom

    发明人： Magnus Hook ,  Kjell Martin Lindberg ,  Torkel Mikael Wadstrom

    IPC分类号： A61K39/085 ,  A61P31/04

    CPC分类号： A61K39/085 ,  Y10S424/823

    摘要： The invention is concerned with a vaccine composition comprising an effective amount of an isolated protein derived from Staphylococcal aureus having the ability to bind fibronectin. The protein has a molecular weight of 165,000 daltons and optionally also contains a protein having a molecular weight of 87,000 daltons. The protein has the ability to elicit antibody production and a level of protein to elicit antibody production. The level of protein is sufficient to produce protection upon challenge with a Staphylococcus aureus bacterial strain in a mammal, particularly a ruminant, by forming antibodies against the Staphylococcus aureus bacterial strain.

    摘要翻译： 本发明涉及包含有效量的具有结合纤连蛋白能力的金黄色葡萄球菌的分离蛋白质的疫苗组合物。 蛋白质的分子量为165,000道尔顿，并且任选地还含有分子量为87,000道尔顿的蛋白质。 该蛋白质具有引发抗体产生和蛋白质水平以引发抗体产生的能力。 通过形成针对金黄色葡萄球菌细菌菌株的抗体，蛋白质水平足以在用金黄色葡萄球菌细菌菌株在哺乳动物，特别是反刍动物中产生保护。