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1.发明申请公开(公告)号：US20100160895A1
公开(公告)日：2010-06-24
申请号：US12716184
申请日：2010-03-02
IPC分类号： A61M5/00
CPC分类号： A61K38/29 , A61K9/0021 , A61K47/12 , A61K47/183 , A61K47/26 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
摘要翻译： 一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或 表皮和真皮层。 在一个实施方案中，基于PTH的试剂包含在施加到微喷射构件的生物相容性涂层中。
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公开(公告)号：US20100119568A1
公开(公告)日：2010-05-13
申请号：US12455830
申请日：2009-06-08
CPC分类号： A61K38/29 , A61K9/0021 , A61K47/12 , A61K47/183 , A61K47/26 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
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公开(公告)号：US09295714B2
公开(公告)日：2016-03-29
申请号：US12455830
申请日：2009-06-08
IPC分类号： A61K38/29 , C07K14/635 , A61M31/00 , A61M37/00 , A61K9/00 , A61K47/12 , A61K47/18 , A61K47/26
CPC分类号： A61K38/29 , A61K9/0021 , A61K47/12 , A61K47/183 , A61K47/26 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
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4.发明授权公开(公告)号：US08633159B2
公开(公告)日：2014-01-21
申请号：US12716184
申请日：2010-03-02
IPC分类号： A61P5/18 , A61M5/30 , C07K14/635 , A61K38/16
CPC分类号： A61K38/29 , A61K9/0021 , A61K47/12 , A61K47/183 , A61K47/26 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
摘要翻译： 一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或 表皮和真皮层。 在一个实施方案中，基于PTH的试剂包含在施加到微喷射构件的生物相容性涂层中。
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5.发明申请Apparatus and Method for Transdermal Delivery of Parathyroid Hormone Agents to Prevent or Treat Osteopenia 审中-公开用于透皮递送甲状旁腺激素试剂以预防或治疗骨质减少的装置和方法公开(公告)号：US20080039775A1
公开(公告)日：2008-02-14
申请号：US11686909
申请日：2007-03-15
申请人： Mahmoud Ameri , Michel Cormier , Yuh-Fun Maa , Marika Kamberi , Peter Daddona
发明人： Mahmoud Ameri , Michel Cormier , Yuh-Fun Maa , Marika Kamberi , Peter Daddona
IPC分类号： A61B17/20
CPC分类号： A61K9/0021 , A61K38/29 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： An apparatus and method for transdermally delivering a biologically active agent to prevent or treat osteopenia, comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
摘要翻译： 一种用于透皮递送生物活性剂以预防或治疗骨质减少的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括适于刺穿角质层的多个微突出物（或阵列） 底层表皮层，或表皮层和真皮层。 在一个实施方案中，基于PTH的试剂包含在施加到微喷射构件的生物相容性涂层中。
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6.发明授权公开(公告)号：US07556821B2
公开(公告)日：2009-07-07
申请号：US11084634
申请日：2005-03-18
CPC分类号： A61K38/29 , A61K9/0021 , A61K47/12 , A61K47/183 , A61K47/26 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
摘要翻译： 一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或 表皮和真皮层。 在一个实施方案中，基于PTH的试剂包含在施加到微喷射构件的生物相容性涂层中。
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7.发明申请公开(公告)号：US20050256045A1
公开(公告)日：2005-11-17
申请号：US11084634
申请日：2005-03-18
申请人： Mahmoud Ameri , Michel Cormier , Yuh-Fun Maa , Marika Kamberi , Peter Daddona
发明人： Mahmoud Ameri , Michel Cormier , Yuh-Fun Maa , Marika Kamberi , Peter Daddona
CPC分类号： A61K38/29 , A61K9/0021 , A61K47/12 , A61K47/183 , A61K47/26 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： An apparatus and method for transdermally delivering a biologically active agent comprising a delivery system having a microprojection member (or system) that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the PTH-based agent is contained in a biocompatible coating that is applied to the microprojection member.
摘要翻译： 一种用于透皮递送生物活性剂的装置和方法，包括具有微突出物构件（或系统）的递送系统，所述微突出物构件（或系统）包括多个微突出物（或阵列），所述微突出物构件（或阵列）适于穿透角质层穿入下面的表皮层，或 表皮和真皮层。 在一个实施方案中，基于PTH的试剂包含在施加到微喷射构件的生物相容性涂层中。
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公开(公告)号：US20060034903A1
公开(公告)日：2006-02-16
申请号：US11201625
申请日：2005-08-10
申请人： Yuh-Fun Maa , Scott Sellers , Peter Daddona , Marika Kamberi , Vidhya Gopalakrishnan , B. Silber , Frank Stonebanks
发明人： Yuh-Fun Maa , Scott Sellers , Peter Daddona , Marika Kamberi , Vidhya Gopalakrishnan , B. Silber , Frank Stonebanks
CPC分类号： A61K9/0021 , A61K9/19 , A61K38/2242 , A61K47/26 , A61M37/00 , A61M37/0015 , A61M2037/0023 , A61M2037/0046
摘要： An apparatus and method for transdermally delivering a natriuretic peptide comprising a delivery system having a microprojection member that includes a plurality of microprojections (or array thereof) that are adapted to pierce through the stratum corneum into the underlying epidermis layer, or epidermis and dermis layers. In one embodiment, the natriuretic peptide is contained in a biocompatible coating that is applied to the microprojection member. In a further embodiment, the delivery system includes a natriuretic peptide-containing hydrogel formulation. In an alternative embodiment, the natriuretic peptide is contained in both the coating and the hydrogel formulation. In yet another embodiment, the natriuretic peptide is contained in a solid state formulation.
摘要翻译： 一种用于经皮递送利尿钠肽的装置和方法，包括具有微突出物构件的递送系统，所述微突出物构件包括多个微突出物（或其阵列），所述微突出物适合于将角质层刺入下面的表皮层或表皮层和真皮层中。 在一个实施方案中，利尿钠肽包含在应用于微喷射构件的生物相容性涂层中。 在另一个实施方案中，递送系统包括含利尿钠肽的水凝胶制剂。 在替代实施方案中，利尿钠肽包含在包衣和水凝胶制剂中。 在另一个实施方案中，利尿钠肽包含在固态制剂中。
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