公开(公告)号：US20240358850A1

公开(公告)日：2024-10-31

申请号：US18633864

申请日：2024-04-12

Applicant: MaineHealth

Inventor： Peter C. Brooks ,  Jennifer M. Caron

IPC: A61K47/68 ,  A61K39/395 ,  A61P35/00

CPC classification number: A61K47/6843 ,  A61K39/3955 ,  A61K47/6803 ,  A61K47/68031 ,  A61K47/68033 ,  A61K47/68035 ,  A61K47/6809 ,  A61P35/00

Abstract: The present invention provides compositions and methods of use thereof in the treatment of cancer and abnormal immune suppression diseases with antibodies an antigen binding fragments thereof which bind collagen and antibody drug conjugates (ADC). In some embodiments, in the methods provided herein the ADCs target non-cell surface targets associated with tumors.

公开(公告)号：US20240327506A1

公开(公告)日：2024-10-03

申请号：US18620778

申请日：2024-03-28

Applicant: MaineHealth

Inventor： Xianghua Han ,  Jennifer M. Caron ,  Peter C. Brooks

IPC: C07K16/18 ,  A61K35/17 ,  A61P35/00 ,  C07K16/28

CPC classification number: C07K16/18 ,  A61K35/17 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2848

Abstract: The present invention provides compositions and methods of use thereof in the treatment of cancer and abnormal immune suppression diseases by enhancing adoptive cell therapy. In some embodiments, the methods provided herein increase T-cell infiltration into a tumor.

公开(公告)号：US11998600B2

公开(公告)日：2024-06-04

申请号：US17110543

申请日：2020-12-03

Applicant: MaineHealth

Inventor： Peter C. Brooks ,  Jennifer M. Caron ,  Liangru Contois

IPC: A61K39/395 ,  A61K38/39 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  A61P37/04 ,  C07K14/78 ,  C07K16/18 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K38/39 ,  A61K39/39558 ,  A61K45/06 ,  A61P35/00 ,  A61P37/04 ,  C07K14/78 ,  C07K16/18 ,  C07K16/2827 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/34 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/76

Abstract: The present invention provides antagonists and methods of use thereof in the treatment of cancer and abnormal immune suppression diseases.