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公开(公告)号：US20110027362A1
公开(公告)日：2011-02-03
申请号：US12866999
申请日：2009-02-10
IPC分类号： A61K9/28 , A61K31/517 , A61P13/00
CPC分类号： A61K9/2054 , A61K9/2018 , A61K9/284 , A61K9/2866 , A61K31/517
摘要： The present invention provides a tablet having improved dissolution property, which comprises (+)-3-{1-[3-(trifluoromethoxy)benzyl]piperidin-4-yl}-4-phenyl-3,4-dihydro-2(1H)-quinazolinone or a pharmaceutically acceptable salt thereof as an active component, and a production method thereof.A film-coated tablet obtained by mixing granulated particles obtained by granulating a mixture containing (a) the aforementioned active component, (b) one or more kinds of fillers selected from lactose, D-mannitol, erythritol and crystalline cellulose, (c) a cellulose-based disintegrant and (d) a water-soluble binder with a later powder containing (e) one or more kinds of fillers selected from lactose, D-mannitol and crystalline cellulose and/or (f) a cellulose-based disintegrant, forming the mixture, and applying film coating. A production method of a film-coated tablet, including a step of producing the granulated particles, a step of producing a tablet by mixing with the later powder and forming the mixture, and a step of applying a film coating to the obtained tablet.
摘要翻译： 本发明提供具有改善的溶解性的片剂，其包含（+） - 3- {1- [3-（三氟甲氧基）苄基]哌啶-4-基} -4-苯基-3,4-二氢-2（1H ） - 喹唑啉酮或其药学上可接受的盐作为活性成分，及其制备方法。 （a）上述活性成分，（b）一种或多种选自乳糖，D-甘露糖醇，赤藓糖醇和结晶纤维素的填料的混合物混合制粒颗粒而得到的薄膜包衣片，（c） 纤维素类崩解剂和（d）具有以下粉末的水溶性粘合剂，所述粉末含有（e）一种或多种选自乳糖，D-甘露糖醇和结晶纤维素的填料和/或（f）纤维素类崩解剂，形成 混合物，并涂覆薄膜涂层。 一种薄膜包衣片的制造方法，包括制造造粒颗粒的步骤，通过与后来的粉末混合制备片剂并形成混合物的步骤，以及将膜包衣涂布在所得片剂上的步骤。
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公开(公告)号：US08673353B2
公开(公告)日：2014-03-18
申请号：US12866999
申请日：2009-02-10
CPC分类号： A61K9/2054 , A61K9/2018 , A61K9/284 , A61K9/2866 , A61K31/517
摘要： The present invention provides a tablet having improved dissolution property, which comprises (+)-3-{1-[3-(trifluoromethoxy)benzyl]piperidin-4-yl}-4-phenyl-3,4-dihydro-2(1H)-quinazolinone or a pharmaceutically acceptable salt thereof as an active component, and a production method thereof.A film-coated tablet obtained by mixing granulated particles obtained by granulating a mixture containing (a) the aforementioned active component, (b) one or more kinds of fillers selected from lactose, D-mannitol, erythritol and crystalline cellulose, (c) a cellulose-based disintegrant and (d) a water-soluble binder with a later powder containing (e) one or more kinds of fillers selected from lactose, D-mannitol and crystalline cellulose and/or (f) a cellulose-based disintegrant, forming the mixture, and applying film coating. A production method of a film-coated tablet, including a step of producing the granulated particles, a step of producing a tablet by mixing with the later powder and forming the mixture, and a step of applying a film coating to the obtained tablet.
摘要翻译： 本发明提供具有改善的溶解性的片剂，其包含（+） - 3- {1- [3-（三氟甲氧基）苄基]哌啶-4-基} -4-苯基-3,4-二氢-2（1H ） - 喹唑啉酮或其药学上可接受的盐作为活性成分，及其制备方法。 （a）上述活性成分，（b）一种或多种选自乳糖，D-甘露糖醇，赤藓糖醇和结晶纤维素的填料的混合物混合制粒颗粒而得到的薄膜包衣片，（c） 纤维素类崩解剂和（d）具有以下粉末的水溶性粘合剂，所述粉末含有（e）一种或多种选自乳糖，D-甘露糖醇和结晶纤维素的填料和/或（f）纤维素类崩解剂，形成 混合物，并涂覆薄膜涂层。 一种薄膜包衣片的制造方法，包括制造造粒颗粒的步骤，通过与后来的粉末混合制备片剂并形成混合物的步骤，以及将膜包衣涂布在所得片剂上的步骤。
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