公开(公告)号：US20130065258A1

公开(公告)日：2013-03-14

申请号：US13699592

申请日：2011-01-28

申请人： Makoto Watanabe ,  Ei-ichi Matsuo ,  Naoki Kaneko ,  Toshiya Matsubara ,  Osamu Nishimura ,  Masaki Mori ,  Ichiro Takemasa

发明人： Makoto Watanabe ,  Ei-ichi Matsuo ,  Naoki Kaneko ,  Toshiya Matsubara ,  Osamu Nishimura ,  Masaki Mori ,  Ichiro Takemasa

IPC分类号： G01N33/574 ,  C07K14/47 ,  G01N21/64

CPC分类号： G01N33/57419 ,  G01N2333/4724

摘要： The present invention provides a tumor screening marker that can be actually used in clinical practice to detect colorectal cancer, and a tumor progression marker that can complement CEA or CA19-9. Galectin-1 used as a tumor screening marker or a tumor progression marker for colorectal cancer. Galectin-3 used as a tumor screening marker. Galectin-4 used as a tumor progression marker, a tumor screening marker, or a prognostic prediction marker for colorectal cancer. A method of analyzing the galectin concentration in a collected blood sample using the galectin. A colorectal cancer marker detection kit comprising a detection antibody selected from the group consisting of a fluorescently labeled galectin-1 antibody, a fluorescently labeled galectin-3 antibody, and a fluorescently labeled galectin-4 antibody.

摘要翻译： 本发明提供可以实际用于临床实践中检测结肠直肠癌的肿瘤筛选标记，以及可补充CEA或CA19-9的肿瘤进展标记。 Galectin-1用作肿瘤筛选标记物或肿瘤进展标志物用于结肠直肠癌。 Galectin-3用作肿瘤筛选标记。 用作肿瘤进展标记物的Galectin-4，肿瘤筛选标记或结肠直肠癌的预后预测标记物。 使用半乳凝素分析收集的血液样品中的半乳凝素浓度的方法。 一种包含选自荧光标记的半乳凝素-1抗体，荧光标记的半乳凝素-3抗体和荧光标记的半乳凝素-4抗体的检测抗体的结肠直肠癌标志物检测试剂盒。