公开(公告)号：US5560914A

公开(公告)日：1996-10-01

申请号：US501751

申请日：1995-07-12

申请人： Mamdooh H. Ghoneum ,  Hiroaki Maeda

发明人： Mamdooh H. Ghoneum ,  Hiroaki Maeda

IPC分类号： C12N9/14 ,  A61K31/715 ,  A61K36/899 ,  A61K39/39 ,  A61P37/04 ,  C08B37/00 ,  C12P19/04 ,  C12P19/20 ,  C12R1/645 ,  C12R1/69 ,  A61K35/78 ,  C12N1/14

CPC分类号： A61K39/39 ,  Y10S435/911

摘要： In a method of producing an immunopotentiator, a plant tissue material is extracted with hot water, the insoluble material is filtered, and the filtrate thereof is treated with glucoamylase to decompose a starch, thereby obtaining a water-soluble polysaccharide. Ammonium sulfate is added in a culture filtrate obtained by culturing any one of Asp Oryzae of the Aspergillaceae and Lentinus edodes of the Basidiomycetes to obtain an enzyme complex from the precipitate. The water-soluble polysaccharide and the enzyme complex are added together to cause them to react at a pH of 4.5 for 30 to 60 minutes and then at a pH of 6.0 for 30 to 60 minutes, thereby biologically modifying the water-soluble polysaccharide.

摘要翻译： 在制造免疫增强剂的方法中，用热水提取植物组织物质，过滤不溶物，将其滤液用葡糖淀粉酶处理，分解淀粉，得到水溶性多糖。 将硫酸铵加入通过培养曲霉的Asp Oryzae和担子菌的香菇中的任一种获得的培养滤液中，从沉淀物中获得酶复合物。 将水溶性多糖和酶复合物加入到一起，使它们在4.5的pH下反应30至60分钟，然后在6.0的pH下反应30至60分钟，从而对水溶性多糖进行生物修饰。