公开(公告)号：US20080021192A1

公开(公告)日：2008-01-24

申请号：US11773864

申请日：2007-07-05

申请人： Mani Iyer ,  Corinne Bauer ,  Pat Oliver-shaffer

发明人： Mani Iyer ,  Corinne Bauer ,  Pat Oliver-shaffer

IPC分类号： C08G69/10

CPC分类号： C07K14/001 ,  C08G69/10 ,  Y02P20/55

摘要： The presently disclosed subject matter provides a novel method for preparing copolymer-1. In one embodiment, a mixture of N-carboxyanhydrides (NCAs) comprising alanine, protected-glutamic acid, protected lysine, and tyrosine, and wherein glutamic acid includes a benzyl or methoxy protecting group and lysine includes a cyclic imide or Boc protecting group are treated with a polymerization initiator to initiate polymerization of the mixture of N-carboxyanhydrides and to thereby synthesize a protected copolymer-1. The protected copolymer-1 can then be treated with deprotecting groups and/or depolymerized to obtain a copolymer-1 having a desired molecular weight.

摘要翻译： 目前公开的主题提供了一种制备共聚物-1的新方法。 在一个实施方案中，包含丙氨酸，被保护的谷氨酸，被保护的赖氨酸和酪氨酸的N-羧酸酐（NCA）和其中谷氨酸包括苄基或甲氧基保护基和赖氨酸的混合物包括环状酰亚胺或Boc保护基团被处理 用聚合引发剂引发N-羧酸酐混合物的聚合，从而合成受保护的共聚物-1。 然后可以用去保护基团处理保护的共聚物-1和/或解聚以获得具有所需分子量的共聚物-1。