公开(公告)号：US07820654B2

公开(公告)日：2010-10-26

申请号：US11234695

申请日：2005-09-23

申请人： Manojit Pal ,  Srinivas Kalleda ,  Srinivas Padakanti ,  Nalivela Kumara Swamy ,  Koteswar Rao Yeleswarapu ,  Christopher W. Alexander ,  Ish Khanna ,  Javed Iqbal ,  Sivaram Pillarisetti ,  Deepak Barange

发明人： Manojit Pal ,  Srinivas Kalleda ,  Srinivas Padakanti ,  Nalivela Kumara Swamy ,  Koteswar Rao Yeleswarapu ,  Christopher W. Alexander ,  Ish Khanna ,  Javed Iqbal ,  Sivaram Pillarisetti ,  Deepak Barange

IPC分类号： A61K31/54 ,  A61K31/535 ,  A61K31/497 ,  A61K31/505 ,  C07D417/00 ,  C07D413/00 ,  C07D403/00 ,  C07D239/02

CPC分类号： C07D405/14 ,  C07D239/30 ,  C07D239/40 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/54 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12

摘要： The present invention is directed to a compounds, methods and compositions for making the compounds and methods of treating a variety of diseases and disease states including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan, comprising the administration of new heterocyclic compounds, particularly substituted pyrimidines. The present invention is directed to novel compounds represented by the general formula:

摘要翻译： 本发明涉及用于制备化合物的化合物，方法和组合物以及治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常或由Perlecan低表达介导的疾病 包括施用新的杂环化合物，特别是取代的嘧啶。 本发明涉及由以下通式表示的新化合物：