公开(公告)号：US08628822B2

公开(公告)日：2014-01-14

申请号：US12145051

申请日：2008-06-24

申请人： Marc L Rothstein ,  Dianne M Rothstein ,  Dan P Lee

发明人： Marc L Rothstein ,  Dianne M Rothstein ,  Dan P Lee

IPC分类号： B05D7/00

CPC分类号： C07H21/00 ,  C03C11/00 ,  C03C17/32 ,  C03C17/328 ,  G01N33/54313 ,  G01N33/54353 ,  G01N33/552 ,  Y10T428/2989 ,  Y10T428/2996 ,  Y10T428/2998

摘要： A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within 1½ hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon.

摘要翻译： 提供了一种制备交联聚合物涂层控制孔隙玻璃（CPG）颗粒的方法。 该方法包括在低于10℃的温度下将CPG颗粒混合在包含聚乙烯基苄基氯和第一溶剂的溶液中。加入第二溶剂并向混合物中加入交联剂。 第一溶剂在加入交联剂的1小时内迅速除去。 允许交联反应进行，然后将混合物冷却并处理以除去任何残留的溶剂。 将所得涂覆的CPG颗粒洗涤并干燥。 还提供了用于在其上负载配体的聚合物涂覆的CPG颗粒。