公开(公告)号：US07838211B2

公开(公告)日：2010-11-23

申请号：US10522909

申请日：2003-07-31

申请人： Marc Preaudat ,  Chikashi Tokuda ,  Laurence Jacquemart

发明人： Marc Preaudat ,  Chikashi Tokuda ,  Laurence Jacquemart

IPC分类号： C12Q1/00

CPC分类号： C12Q1/34

摘要： The invention relates to a method for determining endoglycosidase enzyme activity, and in particular of the heparanase type, in a sample, and also to a method for detecting a compound capable of modulating the activity of an endoglycosidase, and in particular of an endoglycosidase having activity of the heparanase type, by measuring a signal resulting from a close proximity transfer between two compounds attached to a substrate for the enzyme.

摘要翻译： 本发明涉及一种测定样品中糖苷内切酶酶活性，特别是乙酰肝素酶类型的方法，还涉及一种检测能调节内切糖苷酶活性的化合物的方法，尤其涉及具有活性的糖苷内切酶 的乙酰肝素酶类型，通过测量由连接到酶底物的两种化合物之间的紧密转移而产生的信号。

公开(公告)号：US20060127945A1

公开(公告)日：2006-06-15

申请号：US10522909

申请日：2003-07-31

申请人： Marc Preaudat ,  Chikashi Tokuda ,  Laurence Jacquemart

发明人： Marc Preaudat ,  Chikashi Tokuda ,  Laurence Jacquemart

IPC分类号： G01N33/53 ,  C07F5/00 ,  C12Q1/34

CPC分类号： C12Q1/34

摘要： The invention relates to a method for determining endoglycosidase enzyme activity, and in particular of the heparanase type, in a sample, and also to a method for detecting a compound capable of modulating the activity of an endoglycosidase, and in particular of an endoglycosidase having activity of the heparanase type, by measuring a signal resulting from a close proximity transfer between two compounds attached to a substrate for the enzyme.

摘要翻译： 本发明涉及一种测定样品中糖苷内切酶酶活性，特别是乙酰肝素酶类型的方法，还涉及一种检测能调节内切糖苷酶活性的化合物的方法，尤其涉及具有活性的糖苷内切酶 的乙酰肝素酶类型，通过测量由连接到酶底物的两种化合物之间的紧密转移而产生的信号。