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1.发明申请ANTITUMOR COMBINATION COMPRISING A MORPHOLINYL ANTHRACYCLINE DERIVATIVE AND DEMETHYLATING AGENTS 审中-公开包含吗啉基蒽醌衍生物和脱乙酰基化剂的抗肿瘤剂组合公开(公告)号：US20110021517A1
公开(公告)日：2011-01-27
申请号：US12918938
申请日：2009-02-25
IPC分类号： A61K31/5377 , A61P35/00
CPC分类号： A61K45/06 , A61K31/53 , A61K31/5377 , A61K2300/00
摘要： The present invention provides a combination of a morpholinyl anthracycline derivative, in particular a methoxy morpholino doxorubicin derivative, or a pharmaceutically acceptable salt thereof, and a demethylating agent, having an antineo-plastic effect. Also provided is the use of the said combinations in the treatment or prevention of metastasis, in the treatment of tumors, as well for reversing the resistance in cells resistant to such a methoxy morpholino doxorubicin derivative.
摘要翻译： 本发明提供具有抗肿瘤效果的吗啉基蒽环衍生物，特别是甲氧基吗啉代多柔比星衍生物或其药学上可接受的盐和去甲基化剂的组合。 还提供了所述组合在治疗或预防转移中，在治疗肿瘤中的用途，以及用于逆转对这种甲氧基吗啉代多柔比星衍生物具有抗性的细胞耐药性。
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公开(公告)号：US08940334B2
公开(公告)日：2015-01-27
申请号：US12599331
申请日：2008-04-30
IPC分类号： A61K9/14 , A61K31/706 , A61K9/16 , A61K9/50 , A61K9/00 , A61K31/535 , A61K31/704
CPC分类号： A61K9/0019 , A61K31/535 , A61K31/704
摘要： The present invention relates to pharmaceutical composition containing nemorubicin hydrochloride incorporated in microspheres. The compositions are useful for chemoembolization, particularly for loco regional treatment of tumors.
摘要翻译： 本发明涉及含有纳米微球的盐酸诺 该组合物可用于化疗栓塞，特别是用于肿瘤局部区域治疗。
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公开(公告)号：US20120121716A1
公开(公告)日：2012-05-17
申请号：US12599331
申请日：2008-04-30
IPC分类号： A61K31/706 , A61P35/00 , A61P35/04 , A61K9/14
CPC分类号： A61K9/0019 , A61K31/535 , A61K31/704
摘要： The present invention relates to pharmaceutical composition containing nemorubicin hydrochloride incorporated in microspheres. The compositions are useful for chemoembolisation, particularly for loco regional treatment of tumors.
摘要翻译： 本发明涉及含有纳米微球的盐酸诺 组合物可用于化学栓塞，特别是用于局部区域治疗肿瘤。
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4.发明申请MORPHOLINYL ANTHRACYCLINE DERIVATIVE COMBINED WITH PROTEIN KINASE INHIBITORS 审中-公开与蛋白激酶抑制剂组合的吗啡啉安非他酮衍生物公开(公告)号：US20100190736A1
公开(公告)日：2010-07-29
申请号：US12671246
申请日：2008-07-23
IPC分类号： A61K31/706 , A61P35/00
CPC分类号： A61K45/06 , A61K31/706 , A61K2300/00
摘要： The present invention provides the combined use of a morpholinyl anthracycline derivative of formula (I) as defined in the specification or a pharmaceutically acceptable salt thereof, such as nemorubicin hydrochloride, and a protein kinase (PK) inhibitor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.
摘要翻译： 本发明提供了在说明书中定义的式（I）的吗啉基蒽环类衍生物或其药学上可接受的盐，例如盐酸诺日春星和蛋白激酶（PK）抑制剂在肿瘤治疗中的组合使用。 还提供了所述组合在治疗或预防转移中或在通过抑制血管生成治疗肿瘤中的用途。
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5.发明申请Method for treating liver cancer by intrahepatic administration of nemorubicin 审中-公开通过肝内给予伊马菌素治疗肝癌的方法公开(公告)号：US20060264388A1
公开(公告)日：2006-11-23
申请号：US10546234
申请日：2004-02-11
申请人： Olga Valota , Maria Facciarini
发明人： Olga Valota , Maria Facciarini
IPC分类号： A61K31/704 , A61K31/22
CPC分类号： A61K31/706
摘要： The present invention relates to a treatment schedule of nemorubicin administered via the intrahepatic artery in a dosage ranging from about 100 mcg/m2 to about 800 mcg/m2 every 6 weeks to patients with a liver cancer.
摘要翻译： 本发明涉及通过肝内动脉给药的奈米柔宁的治疗方案，其剂量范围为每六周一次肝癌患者约100mcg / m 2至约800mcg / m 2。
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