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1.发明申请RE-EPITHELIALIZING PHARMACEUTICAL COMPOSITIONS COMPRISING XANTHAN GUM 审中-公开包含XANTHAN GUM的药物组合物的重新上皮化公开(公告)号：US20080139502A1
公开(公告)日：2008-06-12
申请号：US12031483
申请日：2008-02-14
IPC分类号： A61K31/723 , A61P17/02
CPC分类号： A61K31/723 , A61K9/0048 , A61K9/06 , A61K31/573 , A61K31/661 , A61K31/7036 , A61K31/715 , A61K31/728 , A61K47/36 , A61K2300/00
摘要： The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.
摘要翻译： 本发明涉及黄原胶作为再上皮剂，尤其涉及包含黄原胶作为最终与透明质酸混合的再上皮化活性成分的药物制剂的用途。 所述使用和组合物加速并有利地改善新生的上皮的形成。
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公开(公告)号：US20080139522A1
公开(公告)日：2008-06-12
申请号：US12031495
申请日：2008-02-14
IPC分类号： A61K31/573
CPC分类号： A61K31/723 , A61K9/0048 , A61K9/06 , A61K31/573 , A61K31/661 , A61K31/7036 , A61K31/715 , A61K31/728 , A61K47/36 , A61K2300/00
摘要： The present invention relates to the use of xanthan gum as re-epithelializing agent and, in particular, to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle eventually mixed with hyaluronic acid. Said use and composition speed up and improve advantageously the formation of newly grown epithelium.
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公开(公告)号：US08912164B2
公开(公告)日：2014-12-16
申请号：US10512521
申请日：2003-04-24
IPC分类号： A01N43/04 , A61K31/715 , A61K9/06 , A61K9/00 , A61K31/723 , A61K47/36 , A61K31/573
CPC分类号： A61K31/723 , A61K9/0048 , A61K9/06 , A61K31/573 , A61K31/661 , A61K31/7036 , A61K31/715 , A61K31/728 , A61K47/36 , A61K2300/00
摘要： The present invention relates to a pharmaceutical formulation comprising xanthan gum as a re-epithelializing active principle optionally mixed with hyaluronic acid. The composition speeds up and improves advantageously the formation of newly grown epithelium.
摘要翻译： 本发明涉及包含黄原胶作为任选与透明质酸混合的再上皮化活性成分的药物制剂。 组合物加速并有利地改善新生的上皮细胞的形成。
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4.发明申请Ophthalmic Pharmaceutical Composition Containing Amphiphilic Polyaspartamide Copolymers 审中-公开包含两亲性聚天冬酰胺共聚物的眼科药物组合物公开(公告)号：US20090221545A1
公开(公告)日：2009-09-03
申请号：US12293148
申请日：2007-03-15
申请人： Gaetano Giammona , Gennara Cavallaro , Mariano Licciardi , Claudine Civiale , Grazia Maria Paladino , Maria Grazia Mazzone
发明人： Gaetano Giammona , Gennara Cavallaro , Mariano Licciardi , Claudine Civiale , Grazia Maria Paladino , Maria Grazia Mazzone
IPC分类号： A61K31/56
CPC分类号： A61K9/0048 , A61K9/1075
摘要： The present invention relates in general to the use of amphiphilic graft-type copolymers of polyaspartamide for the ophthalmic administration of drugs, such as for example steroidal and non-steroidal anti-inflammatory agents, antimicrobial agents such as aminoglycosides, macrolides, cephalosporin, tetracycline, quinolones, penicillin, beta-lactams, anti-glaucoma agents such as prostaglandins, alpha- and beta-blockers, inhibitors of carbonic anhydrase, cannabinoids, antiviral agents, diagnostic agents, anti-angiogenic agents, antioxidants.
摘要翻译： 本发明一般涉及聚天冬氨酰胺的两亲性接枝型共聚物用于眼用药物，例如甾体和非甾体抗炎剂，抗微生物剂如氨基糖苷类，大环内酯类，头孢菌素，四环素类， 喹诺酮类，青霉素类，β-内酰胺类，抗青光眼药如前列腺素，α-和β-阻滞剂，碳酸酐酶抑制剂，大麻素，抗病毒剂，诊断剂，抗血管生成剂，抗氧化剂。
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5.发明申请OPHTHALMIC COMPOSITIONS FOR TREATING PATHOLOGIES OF THE POSTERIOR SEGMENT OF THE EYE 审中-公开用于治疗眼睛前期分期病理学的眼科组合物公开(公告)号：US20110117189A1
公开(公告)日：2011-05-19
申请号：US13003143
申请日：2008-07-08
IPC分类号： A61K9/127 , A61K31/573 , A61K9/14 , A61P27/02 , A61P31/00
CPC分类号： A61K9/0048 , A61K9/06 , A61K31/573 , A61K47/36
摘要： New compositions for ophthalmic use for the prevention and therapy of pathologies of the posterior segment of the eye. These compositions utilize xanthan gum as an active principle carrier, and can be advantageously administered as liquid-gel eye drops on the surface of the eye and optionally used in combination with other therapies for the treatment of the same pathologies.
摘要翻译： 用于眼部用于预防和治疗眼后段病理的新组合物。 这些组合物使用黄原胶作为活性主体载体，并且可以有利地作为液体凝胶滴眼剂施用在眼睛表面上，并任选地与其它疗法组合用于治疗相同病理学。
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公开(公告)号：US06277829B1
公开(公告)日：2001-08-21
申请号：US09472209
申请日：1999-12-27
IPC分类号： A61K3170
CPC分类号： A61K9/0048 , A61K31/7048 , Y10S514/912 , Y10S514/914
摘要： The present invention describes a process for the preparation of aqueous formulations containing azithromycin for ophthalmic use, as well any formulations obtained by this process and their topical use in the ocular bacterial infections, more preferably in the treatment of conjunctivitis, keratitis and blepharitis.
摘要翻译： 本发明描述了一种制备含有用于眼科用途的阿奇霉素的水性制剂的方法，以及通过该方法获得的任何制剂及其在眼部细菌感染中的局部用途，更优选治疗结膜炎，角膜炎和睑炎。
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7.发明授权Pharmaceutical formulations based on apolar and polar lipids for ophthalmic use 有权基于用于眼科用途的非极性和极性脂质的药物制剂公开(公告)号：US09161906B2
公开(公告)日：2015-10-20
申请号：US12593075
申请日：2007-12-24
申请人： Maria Grazia Mazzone , Valeria Maria Carmela Moschetti , Fausto Giuseppe Miano , Letizia Gaetana Lo Grasso
发明人： Maria Grazia Mazzone , Valeria Maria Carmela Moschetti , Fausto Giuseppe Miano , Letizia Gaetana Lo Grasso
CPC分类号： A61K9/0048 , A61K47/24 , A61K47/44
摘要： The present invention refers to pharmaceutical formulations based on lipids for ophthalmic use comprising a phospholipid component composed of zwitterionic phospholipids of natural origin and an oily component composed of oils of natural origin emulsified in water. In particular, the invention refers to ophthalmic formulations useful, for example, for transporting drugs to the eye and in the treatment of ocular dryness, capable of restoring the lipid layer of the tear film. In particular, in a non-transitory but pathological situation such as the dry eye syndrome, such formulations also succeed in reducing the often-present inflammatory component.
摘要翻译： 本发明涉及基于用于眼用的脂质的药物制剂，其包含由天然来源的两性离子磷脂组成的磷脂成分和由在水中乳化的天然来源的油组成的油性成分。 特别地，本发明涉及可用于例如将药物输送到眼睛和治疗眼睛干燥的眼用制剂，其能够恢复泪液膜的脂质层。 特别地，在诸如干眼综合征之类的非暂时但病态的情况下，这样的制剂也能成功地减少经常存在的炎症组分。
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8.发明申请OPHTHALMIC PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF NEOANGIOGENIC PATHOLOGIES OF THE EYE 审中-公开用于治疗眼睛新生儿病理学的眼科药物组合物公开(公告)号：US20110142923A1
公开(公告)日：2011-06-16
申请号：US13057940
申请日：2009-08-06
IPC分类号： A61K31/44 , A61P27/02 , A61P27/06 , A61K9/127 , A61K31/713 , A61K39/395 , A61K38/02 , A61K31/65 , A61K31/43 , A61K31/545
CPC分类号： A61K31/44 , A61K9/0048 , A61K45/06 , A61K2300/00
摘要： The present invention relates to ophthalmic pharmaceutical compositions comprising Sorafenib, its derivatives or active metabolites, for the treatment and prevention of ocular neoangiogenic pathologies.
摘要翻译： 本发明涉及眼药物组合物，其包含索拉非尼，其衍生物或活性代谢物，用于治疗和预防眼部新生血管生成病理。
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