公开(公告)号：US20050026167A1

公开(公告)日：2005-02-03

申请号：US10732374

申请日：2003-12-11

申请人： Mark Birch-Machin ,  Gabriel Dakubo ,  Ryan Parr ,  Robert Thayer ,  Alioune Ngom ,  John Th'ng

发明人： Mark Birch-Machin ,  Gabriel Dakubo ,  Ryan Parr ,  Robert Thayer ,  Alioune Ngom ,  John Th'ng

IPC分类号： C07H21/04 ,  C12Q1/68 ,  G06F19/18 ,  C12P19/34

CPC分类号： C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2600/158 ,  G16B20/00

摘要： The examination of mutations in the mitochondrial genome is used as a diagnostic system for diseases such as prostate cancer, and non melanoma skin cancer. Characteristic mutations and rearrangements including, point mutations (transitions, transversions), deletions, inversions, duplications, recombinations, insertions or combinations thereof in the mitochondrial genome are used as early indicators of prostate cancer, and non melanoma skin cancer. Moreover, the 4977 bp, or “common deletion” as well as other associated mutations and/or deletions are used as a measure of aging.

摘要翻译： 线粒体基因组中突变的检测用作前列腺癌和非黑色素瘤皮肤癌等疾病的诊断系统。 线粒体基因组中的特征突变和重排，包括点突变（转换，转换），缺失，逆转，重复，重组，插入或其组合用作前列腺癌和非黑色素瘤皮肤癌的早期指标。 此外，使用4977bp或“常见缺失”以及其他相关突变和/或缺失作为衰老的量度。