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    Compositions comprising C-13 alkoxyether macrolide compounds and phenylpyrazole compounds
    3.
    发明授权
    Compositions comprising C-13 alkoxyether macrolide compounds and phenylpyrazole compounds 有权
    包含C-13烷氧基醚大环内酯化合物和苯基吡唑化合物的组合物

    公开(公告)号：US07919522B2

    公开(公告)日：2011-04-05

    申请号：US11799796

    申请日：2007-05-03

    申请人： Mark D. Soll ,  Albert Boeckh ,  Natalya Shub

    发明人： Mark D. Soll ,  Albert Boeckh ,  Natalya Shub

    IPC分类号： A61K31/335 ,  C07D309/30

    CPC分类号： A61K45/06 ,  A01N43/56 ,  A01N47/02 ,  A61K31/415 ,  A61K31/4439 ,  A61K31/70 ,  C07D493/22 ,  A01N43/90 ,  A01N2300/00 ,  A61K2300/00

    摘要： Provided is a novel ivermectin derivative and compositions for the treatment or prophylaxis of parasite infestations in mammals or birds which comprise: (A) a pharmaceutically effective amount of a 1-N-phenylpyrazole compound; (B) a pharmaceutically effective amount of an ivermectin derivative of formula (II) wherein: R14 represents —(CH2)s—O—Z wherein, s is 1 or 2; Y represents —CH(OR15)—, —C(═O)— or —C(═NOR15); R15 represents hydrogen, alkyl or phenyl; and R16 represents —CH3 or —CH2CH3; Z is alkyl, alkenyl, alkynyl, acyl, alkylalkoxy, aryl, alkanoyloxy, alkoxycarbonyl, alkenoyl, alkynoyl, or aroyl.

    摘要翻译： 提供了一种新颖的伊维菌素衍生物和用于治疗或预防哺乳动物或鸟类中寄生虫侵袭的组合物，其包含：（A）药学有效量的1-N-苯基吡唑化合物; （B）药学有效量的式（II）的伊维菌素衍生物，其中：R14表示 - （CH2）s-O-Z，其中s为1或2; Y表示-CH（OR 15） - ， - C（= O） - 或-C（= NOOR 15）。 R 15表示氢，烷基或苯基; R 16表示-CH 3或-CH 2 CH 3; Z是烷基，烯基，炔基，酰基，烷基烷氧基，芳基，烷酰氧基，烷氧基羰基，烯酰基，炔酰基或芳酰基。

    Spot-on formulations for combating parasites
    5.
    发明授权
    Spot-on formulations for combating parasites 有权
    用于防治寄生虫的现货配方

    公开(公告)号：US06998131B2

    公开(公告)日：2006-02-14

    申请号：US10279356

    申请日：2002-10-24

    申请人： Mark D. Soll ,  Albert Boeckh

    发明人： Mark D. Soll ,  Albert Boeckh

    IPC分类号： A01N25/32

    CPC分类号： A01N43/56 ,  A01N47/02 ,  A61K31/70 ,  A01N2300/00 ,  A61K2300/00

    摘要： In particular this invention provides for spot-on compositions for the treatment or prophylaxis of parasite infestations in mammals or birds which comprise: (1) a composition comprising (A) an effective amount of a 1-phenylpyrazole derivative; and (B) an effective amount of emamectin; (2) an acceptable liquid carrier vehicle; and (3) optionally, a crystallization inhibitor. The invention also provides for a method of treating parasitic infestations or for the prophylaxis of parasite infestations in mammals or birds which comprises topically applying to said mammal treating parasitic infestations or for the prophylaxis of parasite infestations in mammals or birds which comprises topically applying to said mammal or bird an effective amount of a composition according to the present invention.

    摘要翻译： 特别地，本发明提供了用于治疗或预防哺乳动物或鸟类中的寄生虫感染的斑点组合物，其包括

    Long acting injectable formulations
    6.
    发明授权
    Long acting injectable formulations 有权
    长效注射制剂

    公开(公告)号：US08362086B2

    公开(公告)日：2013-01-29

    申请号：US11207980

    申请日：2005-08-19

    申请人： Mark D. Soll ,  Peter Hanson ,  Krishan Kumar ,  Monica Tejwani-Motwani

    发明人： Mark D. Soll ,  Peter Hanson ,  Krishan Kumar ,  Monica Tejwani-Motwani

    IPC分类号： A61K31/63 ,  A61K31/7048

    CPC分类号： A61K31/00 ,  A61K9/0019 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34 ,  A61K48/00

    摘要： The application relates to long acting injectable (LAI) formulations for combating ectoparasites and endoparasites in mammals. In particular, this invention provides for a LAI formulation comprising a subcutaneously volatile solvent, a biologically acceptable polymer, a bioactive agents and optionally one or more anti-ectoparasitically or anti-endoparasitically acceptable additive or excipient. Surprisingly, the liquid long acting injectable formulations of the invention solve the problems associates with previous injectable formulations by having long term stability, being able to accommodate smaller needle diameters and achieving long acting effects in the control of pests in a mammal. The unique formulations of the invention also allow for combating ectoparasites and endoparasites which have become resistant to macrolide antibiotics.

    摘要翻译： 本申请涉及用于对抗哺乳动物体内寄生虫和内寄生虫的长效注射剂（LAI）制剂。 特别地，本发明提供了包含皮下挥发性溶剂，生物学上可接受的聚合物，生物活性剂和任选的一种或多种抗外寄生物或抗内分泌上可接受的添加剂或赋形剂的LAI制剂。 令人惊奇的是，本发明的液体长效注射制剂通过具有长期稳定性能够解决与先前可注射制剂相关的问题，能够适应较小的针头直径并且实现控制哺乳动物中害虫的长效应。 本发明的独特配方还允许抵抗已经变得对大环内酯类抗生素具有抗性的外寄生物和内寄生虫。

    Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz
    7.
    发明授权
    Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz 有权
    包含1-N-芳基吡唑衍生物和氨基拉唑的局部制剂

    公开(公告)号：US07531186B2

    公开(公告)日：2009-05-12

    申请号：US10783459

    申请日：2004-02-20

    申请人： Albert Boeckh ,  Luiz Gustavo Cramer ,  Mark D. Soll

    发明人： Albert Boeckh ,  Luiz Gustavo Cramer ,  Mark D. Soll

    IPC分类号： A01N25/32

    CPC分类号： A01N43/56 ,  A01N47/02 ,  A01N2300/00 ,  A01N37/52

    摘要： The present invention provides for, inter alia, novel topical formulations comprising at least one 1-N-arypyrazole derivative and amitraz and to methods for treating, controlling, or preventing parasite infestations on mammals or birds The inventive formulations include spot-on, pour-on or spray formulations and may include a further ectoparasiticide, such as an IGR compound, an avermectin or milbemycin derivative, or a pyrethroid insecticides, and anthelmintics, such as benzimidazoles and imidazothiazoles. The inventive formulation provides a larger duration of parasite control at a faster rate of control. The inventive formula remains effective up to three months from the first application. Moreover, the inventive formulations prevent tick attachment to the animal, thereby providing protection against tick borne diseases. The ectoparasites which may be controlled, treated or prevented by the present invention includes ticks, fleas, mites, mange, lice, mosquitoes, flies and cattle grubs.

    摘要翻译： 本发明特别提供了包含至少一种1-N-阿吡唑衍生物和氨喋啶的新型局部制剂，以及用于治疗，控制或预防哺乳动物或鸟类寄生虫侵袭的方法。本发明的制剂包括点状， 可以包括另外的外寄生物杀虫剂，例如IGR化合物，除虫菌素或米尔倍霉素衍生物，拟除虫菊酯杀虫剂，以及驱肠虫药如苯并咪唑和咪唑并噻唑。 本发明的配方以更快的控制速率提供更大的寄生虫控制持续时间。 本发明的公式从第一次申请至多三个月仍然有效。 此外，本发明的制剂防止蜱附着于动物，从而提供防止蜱携带疾病的保护。 本发明可以控制，治疗或预防的外寄生虫包括蜱，跳蚤，螨虫，虱子，虱子，蚊子，苍蝇和牛。。。

    Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz
    8.
    发明授权
    Topical formulations comprising 1-N-arylpyrazole derivatives and amitraz 有权
    包含1-N-芳基吡唑衍生物和氨基拉唑的局部制剂

    公开(公告)号：US08242161B2

    公开(公告)日：2012-08-14

    申请号：US12420325

    申请日：2009-04-08

    申请人： Albert Boeckh ,  Luiz Gustavo Cramer ,  Mark D. Soll

    发明人： Albert Boeckh ,  Luiz Gustavo Cramer ,  Mark D. Soll

    IPC分类号： A01N43/56

    CPC分类号： A01N43/56 ,  A01N47/02 ,  A01N2300/00 ,  A01N37/52

    摘要： The present invention provides for, inter alia, novel topical formulations comprising at least one 1-N-arypyrazole derivative and amitraz and to methods for treating, controlling, or preventing parasite infestations on mammals or birds The inventive formulations include spot-on, pour-on or spray formulations and may include a further ectoparasiticide, such as an IGR compound, an avermectin or milbemycin derivative, or a pyrethroid insecticides, and anthelmintics, such as benzimidazoles and imidazothiazoles. The inventive formulation provides a larger duration of parasite control at a faster rate of control. The inventive formula remains effective up to three months from the first application. Moreover, the inventive formulations prevent tick attachment to the animal, thereby providing protection against tick borne diseases. The ectoparasites which may be controlled, treated or prevented by the present invention includes ticks, fleas, mites, mange, lice, mosquitoes, flies and cattle grubs.

    摘要翻译： 本发明特别提供了包含至少一种1-N-阿吡唑衍生物和氨喋啶的新型局部制剂，以及用于治疗，控制或预防哺乳动物或鸟类寄生虫侵袭的方法。本发明的制剂包括点状， 可以包括另外的外寄生物杀虫剂，例如IGR化合物，除虫菌素或米尔倍霉素衍生物，拟除虫菊酯杀虫剂，以及驱肠虫药如苯并咪唑和咪唑并噻唑。 本发明的配方以更快的控制速率提供更大的寄生虫控制持续时间。 本发明的公式从第一次申请至多三个月仍然有效。 此外，本发明的制剂防止蜱附着于动物，从而提供防止蜱携带疾病的保护。 本发明可以控制，治疗或预防的外寄生虫包括蜱，跳蚤，螨虫，虱子，虱子，蚊子，苍蝇和牛。。。

    Topical Formulations Comprising 1-N-Arylpyrazole Derivatives and Amitraz
    9.
    发明申请
    Topical Formulations Comprising 1-N-Arylpyrazole Derivatives and Amitraz 有权
    包含1-N-Arylpyrazole衍生物和Amitraz的局部制剂

    公开(公告)号：US20090192207A1

    公开(公告)日：2009-07-30

    申请号：US12420325

    申请日：2009-04-08

    申请人： Albert Boeckh ,  Luiz Gustavo Cramer ,  Mark D. Soll

    发明人： Albert Boeckh ,  Luiz Gustavo Cramer ,  Mark D. Soll

    IPC分类号： A01N43/56

    CPC分类号： A01N43/56 ,  A01N47/02 ,  A01N2300/00 ,  A01N37/52

    摘要： The present invention provides for, inter alia, novel topical formulations comprising at least one 1-N-arypyrazole derivative and amitraz and to methods for treating, controlling, or preventing parasite infestations on mammals or birds The inventive formulations include spot-on, pour-on or spray formulations and may include a further ectoparasiticide, such as an IGR compound, an avermectin or milbemycin derivative, or a pyrethroid insecticides, and anthelmintics, such as benzimidazoles and imidazothiazoles. The inventive formulation provides a larger duration of parasite control at a faster rate of control. The inventive formula remains effective up to three months from the first application. Moreover, the inventive formulations prevent tick attachment to the animal, thereby providing protection against tick borne diseases. The ectoparasites which may be controlled, treated or prevented by the present invention includes ticks, fleas, mites, mange, lice, mosquitoes, flies and cattle grubs.

    摘要翻译： 本发明特别提供了包含至少一种1-N-阿吡唑衍生物和氨喋啶的新型局部制剂，以及用于治疗，控制或预防哺乳动物或鸟类寄生虫侵袭的方法。本发明的制剂包括点状， 可以包括另外的外寄生物杀虫剂，例如IGR化合物，除虫菌素或米尔倍霉素衍生物，拟除虫菊酯杀虫剂，以及驱肠虫药如苯并咪唑和咪唑并噻唑。 本发明的配方以更快的控制速率提供更大的寄生虫控制持续时间。 本发明的公式从第一次申请至多三个月仍然有效。 此外，本发明的制剂防止蜱附着于动物，从而提供防止蜱携带疾病的保护。 本发明可以控制，治疗或预防的外寄生虫包括蜱，跳蚤，螨虫，虱子，虱子，蚊子，苍蝇和牛。。。