公开(公告)号：US20050176761A1

公开(公告)日：2005-08-11

申请号：US11006042

申请日：2004-12-07

申请人： Marko Pregel ,  Bradford Hirth ,  John Kane ,  Shuang Qiao ,  Jill Gregory ,  Lisa Cuff

发明人： Marko Pregel ,  Bradford Hirth ,  John Kane ,  Shuang Qiao ,  Jill Gregory ,  Lisa Cuff

IPC分类号： A61K31/47 ,  A61K31/4709

CPC分类号： A61K31/4709 ,  A61K31/47

摘要： Tetrhydroisoquinoline derivatives, pharmaceutical compositions comprising them and methods of treating disease are disclosed herein. The disclosed compounds are useful in the treatment and prevention of diseases mediated by chloride channel activity and/or protein trafficking, including, but not limited to, diseases associated with impaired mucociliary clearance such as cystic fibrosis, bronchitis, emphysema, and the like.

摘要翻译： 本文公开了四氢异喹啉衍生物，包含它们的药物组合物和治疗疾病的方法。 所公开的化合物可用于治疗和预防由氯离子通道活性和/或蛋白质运输介导的疾病，包括但不限于与粘液纤毛清除障碍相关的疾病，例如囊性纤维化，支气管炎，肺气肿等。

公开(公告)号：US07541466B2

公开(公告)日：2009-06-02

申请号：US11006042

申请日：2004-12-07

申请人： Marko J. Pregel ,  Bradford H. Hirth ,  John L. Kane, Jr. ,  Shuang Qiao ,  Jill Gregory ,  Lisa Cuff

发明人： Marko J. Pregel ,  Bradford H. Hirth ,  John L. Kane, Jr. ,  Shuang Qiao ,  Jill Gregory ,  Lisa Cuff

IPC分类号： C07D215/12

CPC分类号： A61K31/4709 ,  A61K31/47

摘要： Tetrahydroisoquinoline derivatives, pharmaceutical compositions comprising them and methods of treating disease are disclosed herein. The disclosed compounds are useful in the treatment and prevention of diseases mediated by chloride channel activity and/or protein trafficking, including, but not limited to, diseases associated with impaired mucociliary clearance such as cystic fibrosis, bronchitis, emphysema, and the like.

摘要翻译： 本文公开了四氢异喹啉衍生物，包含它们的药物组合物和治疗疾病的方法。 所公开的化合物可用于治疗和预防由氯离子通道活性和/或蛋白质运输介导的疾病，包括但不限于与粘液纤毛清除障碍相关的疾病，例如囊性纤维化，支气管炎，肺气肿等。